What is the recommended dosage for Niacin?

General: 14-16 mg/day NE (RDA); Cognitive Support: 500-1,500 mg/day niacinamide

What are the side effects of Niacin?

Potential side effects include: Flushing (nicotinic acid form), Gastrointestinal discomfort, Liver toxicity at sustained high doses, Elevated blood sugar.

Niacin (vitamin B3) is an essential nutrient that participates in over 400 enzymatic reactions in the body. It is a precursor to NAD+, a coenzyme critical for cellular energy metabolism and DNA repair. Research has explored niacin's potential role in supporting brain energy metabolism and neuroprotection.

What dosage of Niacin has been used in cognitive studies?

Dietary studies have associated higher niacin intake (around 20 to 45 mg per day) with better cognitive outcomes in older adults. Therapeutic doses used in clinical settings range widely. Niacinamide and nicotinamide riboside are alternative forms that avoid the flushing effect. Consult your doctor.

What are the potential side effects of Niacin?

Immediate-release niacin commonly causes flushing (warmth, redness, and tingling of the skin). High doses may cause liver toxicity, gastrointestinal distress, and elevated blood sugar. Extended-release niacin and niacinamide have different side effect profiles. Consult your healthcare provider.

Niacin

vitamin

Also known as: Vitamin B3, Nicotinic Acid, Nicotinamide, Niacinamide

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About

Niacin is essential for NAD+ and NADP+ coenzymes critical for mitochondrial energy production, DNA repair, and sirtuin activation in neurons. NAD+ depletion is implicated in neurodegeneration and is a major research frontier.

How It Works

Essential precursor to NAD+ and NADP+ coenzymes critical for mitochondrial energy production, DNA repair, and sirtuin activation in neurons; supports cerebral blood flow through vasodilatory effects.

Side Effects

Flushing (nicotinic acid form)
Gastrointestinal discomfort
Liver toxicity at sustained high doses
Elevated blood sugar

Drug & Supplement Interactions

Statins (increased myopathy risk with nicotinic acid)
Antidiabetic drugs (niacin may raise blood sugar)
Alcohol (increases flushing)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Folate Vitamin B12 Vitamin B6 Vitamin D Vitamin E

Quick Facts

Dosage: General: 14-16 mg/day NE (RDA); Cognitive_Support: 500-1,500 mg/day niacinamide
Forms: tablet capsule extended-release tablet
Natural Sources: Poultry, Tuna, Liver, Peanuts, Mushrooms
Upper Limit: 35 mg/day nicotinic acid (flushing); 3,000 mg/day niacinamide
Best Time: With meals to reduce flushing (nicotinic acid form)

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.