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PQQ (Pyrroloquinoline Quinone) per Age-Related Cognitive Decline

C

A double-blind RCT of 64 subjects found 21.5 mg/day PQQ improved memory, attention, and cognitive function after 12 weeks. A separate trial in MCI patients showed cerebral oxygenation increased from 48.4% to 52.8%.

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In sintesi

            
            
A double-blind RCT of 64 subjects found 21.5 mg/day PQQ improved memory, attention, and cognitive function after 12 weeks. A separate trial in MCI patients showed cerebral oxygenation increased from 48.4% to 52.8%.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                6 weeks
                
                
                Double-blind
                
            

            
                The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in …
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Cognitive function
                
                
                Effetto: None
                
                
                P = 0.01
                
            

            
            
Popolazione: Alzheimer's disease patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
4

        
Studi

    

    

        
200

        
Partecipanti

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grado

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The journal of …
                        2024
                        
                        6 citazioni
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosaggi di uso comune

                

                    
                    

                        
general:

                        
10-20 mg/day

                    

                    
                    

                        
cognitivesupport:

                        
20 mg/day

                    

                    
                

                
                

                    Limite massimo: Not established; well-tolerated up to 60 mg/day
                

                
            

            

            
            

                
Dosaggi studiati nella ricerca

                

                    

                        
                            

                                Dosaggio
                                Durata
                                Effetto
                                N
                            

                        
                        
                            
                            

                                None
                                6 weeks
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Momento migliore per l'assunzione: With meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effetti collaterali segnalati

                    
    
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                        
  • 
                            ⚠
                            Insomnia
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild fatigue
                        
    • 
                        
                    

                

                

                
                

                    
Interazioni note

                    
    
                        
                        
  • 
                            ●
                            No significant drug interactions established
                        
    • 
                        
                    

                

                

                
                

                    

                        Livello di assunzione massimo tollerabile: Not established; well-tolerated up to 60 mg/day
                    

                

                
            

            

                Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does PQQ (Pyrroloquinoline Quinone) help with Age-Related Cognitive Decline?
            
        
        

            Based on 4 studies with 200 participants, there is limited but promising evidence that PQQ (Pyrroloquinoline Quinone) may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much PQQ (Pyrroloquinoline Quinone) should I take for Age-Related Cognitive Decline?
            
        
        

            Studies have used various dosages. A commonly studied range is 10-20 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of PQQ (Pyrroloquinoline Quinone)?
            
        
        

            Reported side effects may include Headache, Insomnia, Mild fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for PQQ (Pyrroloquinoline Quinone) and Age-Related Cognitive Decline?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

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        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.