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BrainCited

Creatine Mental Fatigue

B

A systematic review found moderate certainty evidence for positive effects on memory and processing speed. Single-dose supplementation improved cognitive performance during sleep deprivation through ATP replenishment.

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B

結論

A systematic review found moderate certainty evidence for positive effects on memory and processing speed. Single-dose supplementation improved cognitive performance during sleep deprivation through ATP replenishment.

Key Study Findings

Review
Creatine Supplementation and the Brain: Have We Put the Cart Before the Horse?
Dose: None vs: None Outcome: None 効果: None None

対象集団: narrative review of creatine supplementation effects on brain function

Other 24 weeks
Analysis of Incidence and Clinical Characteristics of RSV Infection in Hospitalized Children: A Retrospective Study.
Dose: 71.9% vs: None Outcome: None 効果: None None

対象集団: rsv infection from january 2019 to december 2020

Randomized Controlled Trial Double-blind
Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills?
Dose: 20 g vs: placebo Outcome: throughout the protocol 効果: None P = 0.022

対象集団: healthy participants

Review
Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain …
Dose: 20 g/d vs: Placebo Outcome: None 効果: None None

対象集団: elderly

Cohort Study n=480
Decrease in Serum Vitamin D Level of Older Patients with Fatigue.
Dose: None vs: Control Outcome: Cognitive function 効果: None p=0.05

対象集団: patients with fatigue and 240 controls without fatigue,

Systematic Review n=281
Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized …
Dose: None vs: None Outcome: Cognitive function (memory, intelligence/reasoning) 効果: None None

対象集団: Healthy individuals

Key Statistics

8

研究数

600

参加者数

Positive

B

グレード

Referenced Papers

Nutrition (Burbank, Los … 2009 85 件の引用
Pharmacology, biochemistry, and … 1998 60 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:
3-5 g/day creatine monohydrate
cognitivesupport:
5 g/day

上限量: 5 g/day considered safe for long-term use (ISSN position)

研究で検討された用量

用量 期間 効果 N
None -- Mixed --
71.9% 24 weeks Positive --
20 g -- Positive --
20 g/d -- Positive --
None -- Mixed 480
None -- Positive 281
None -- Positive 16
None -- Positive --

推奨摂取タイミング: Any time of day; with or without food

Safety & Side Effects

報告されている副作用

  • Water retention
  • Mild gastrointestinal discomfort
  • Weight gain (water weight)
  • Muscle cramping (rare, dose-dependent)

既知の相互作用

  • Nephrotoxic drugs (monitor kidney function with concurrent use)
  • Caffeine (may partially attenuate creatine loading, debated)
  • NSAIDs (theoretical additive kidney stress at high doses)

耐容上限摂取量: 5 g/day considered safe for long-term use (ISSN position)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Creatine help with Mental Fatigue?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Creatine may support Mental Fatigue management. Our evidence grade is B (Good Evidence).
How much Creatine should I take for Mental Fatigue?
Studies have used various dosages. A commonly studied range is 3-5 g/day creatine monohydrate. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Creatine?
Reported side effects may include Water retention, Mild gastrointestinal discomfort, Weight gain (water weight), Muscle cramping (rare, dose-dependent). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Creatine and Mental Fatigue?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分: Mental Fatigue

Creatine 他の症状・状態について

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