Rhodiola rosea ： Mental Fatigue
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Multiple RCTs demonstrate significant reduction in mental fatigue and improved concentration during stressful periods. Rosavin and salidroside appear to be the primary active compounds supporting cognitive endurance.
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B
結論
Multiple RCTs demonstrate significant reduction in mental fatigue and improved concentration during stressful periods. Rosavin and salidroside appear to be the primary active compounds supporting cognitive endurance.
Key Study Findings
Randomized Controlled Trial
n=18
Double-blind
The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises …
Dose: 4 days supplementation
vs: Placebo
Outcome: Strength performance in bench-press and bench-pull
効果: 17 small ESs observed, 14 favoring RR
None
対象集団: Young healthy individuals (7 women, 11 men)
Review
Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on …
Dose: None
vs: None
Outcome: Inflammatory markers
効果: None
None
対象集団: Depression patients
Randomized Controlled Trial
4.3 weeks
Single-blind
Assessing brain function in stressed healthy individuals following the use of a combination of green …
Dose: None
vs: placebo
Outcome: Brain response to stress and quality of life
効果: None
p = 0.001
対象集団: Chronically stressed but healthy subjects
Review
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Other
4 weeks
Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance …
Dose: None
vs: Control group
Outcome: acute and chronic effects of resistance exercise coupled …
効果: None
p < 0.05
対象集団: None
Review
Adaptogens in mental and behavioral disorders.
Dose: None
vs: None
Outcome: Stress-protective and stimulative effects
効果: None
None
対象集団: Adults with mental and behavioral disorders
Key Statistics
11
研究数
900
参加者数
↑
Positive
B
グレード
Referenced Papers
Nutrients
2025
6 件の引用
Journal of neural …
2024
8 件の引用
Frontiers in nutrition
2023
3 件の引用
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 件の引用
Journal of the …
2020
25 件の引用
The Psychiatric clinics …
2013
64 件の引用
Rhodiola rosea for physical and mental fatigue: a systematic review.
Systematic Review
BMC complementary and …
2012
114 件の引用
International journal of …
2006
40 件の引用
Medicina (Kaunas, Lithuania)
2004
Phytomedicine : international …
2003
205 件の引用
Phytomedicine : international …
2000
281 件の引用
Phytomedicine : international …
2000
251 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 200-600 mg/day standardized to 3% rosavins and 1% salidroside
上限量： Not established; doses up to 680 mg/day used in trials
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 4 days supplementation | -- | Positive | 18 |
| None | -- | Mixed | -- |
| None | 4.3 weeks | Positive | -- |
| None | -- | Mixed | -- |
| None | 4 weeks | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： Morning on empty stomach; avoid evening (may be stimulating)
Safety & Side Effects
報告されている副作用
- ⚠ Insomnia or overstimulation (if taken late)
- ⚠ Dry mouth
- ⚠ Dizziness
- ⚠ Mild agitation
既知の相互作用
- ● Antidepressants (SSRIs, MAOIs — additive serotonergic effects)
- ● Antidiabetic drugs (may lower blood sugar)
- ● Stimulant medications (additive stimulatory effects)
- ● Immunosuppressants (may modulate immune response)
耐容上限摂取量： Not established; doses up to 680 mg/day used in trials
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Rhodiola rosea help with Mental Fatigue?
Based on 11 studies with 900 participants, there is moderate evidence from clinical studies that Rhodiola rosea may support Mental Fatigue management. Our evidence grade is B (Good Evidence).
How much Rhodiola rosea should I take for Mental Fatigue?
Studies have used various dosages. A commonly studied range is 200-600 mg/day standardized to 3% rosavins and 1% salidroside. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Rhodiola rosea?
Reported side effects may include Insomnia or overstimulation (if taken late), Dry mouth, Dizziness, Mild agitation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Rhodiola rosea and Mental Fatigue?
We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Mental Fatigue
Rhodiola rosea 他の症状・状態について
References
- [1] Daniel Marcos-Frutos et al.. Nutrients. 2025. The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue … doi:10.3390/nu17060940 PubMed
- [2] Juliane K Mueller et al.. J Neural Transm (Vienna). 2024. Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea. doi:10.1007/s00702-024-02749-3 PubMed
- [3] Gisèle Pickering et al.. Front Nutr. 2023. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B … doi:10.3389/fnut.2023.1211321 PubMed
- [4] John E Lewis et al.. J Clin Transl Res. 2021. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. PubMed
- [5] Rémi Roumanille et al.. J Int Soc Sports Nutr. 2020. Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis … doi:10.1186/s12970-020-00390-5 PubMed
- [6] Alexander G Panossian. Psychiatr Clin North Am. 2013. Adaptogens in mental and behavioral disorders. doi:10.1016/j.psc.2012.12.005 PubMed
- [7] Sana Ishaque et al.. BMC Complement Altern Med. 2012. Rhodiola rosea for physical and mental fatigue: a systematic review. doi:10.1186/1472-6882-12-70 PubMed
- [8] Thomas B Walker et al.. Int J Sport Nutr Exerc Metab. 2006. Does Rhodiola rosea possess ergogenic properties? doi:10.1123/ijsnem.16.3.305 PubMed
- [9] Agne Kucinskaite et al.. Medicina (Kaunas). 2004. [Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine]. PubMed
- [10] V A Shevtsov et al.. Phytomedicine. 2003. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for … doi:10.1078/094471103321659780 PubMed
- [11] V Darbinyan et al.. Phytomedicine. 2000. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen … doi:10.1016/S0944-7113(00)80055-0 PubMed
- [12] A A Spasov et al.. Phytomedicine. 2000. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of … doi:10.1016/S0944-7113(00)80078-1 PubMed
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