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Metabolomic profiling of adrenocortical carcinoma cells treated with mitotane, revealing significant alterations in mitochondrial metabolite concentrations. The drug concentrates in mitochondria and disrupts normal metabolic function.

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Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches.

Oncotarget (2017)

PMID: 29299119

DOI: 10.18632/oncotarget.18968

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![Figure 1: Metabolomic profiling of adrenocortical carcinoma cells treated with mitotane, revealing significant alterations in mitochondrial metabolite concentrations. The drug concentrates in mitochondria and disrupts normal metabolic function.]()

> Source: Ségolène Hescot et al. "Identifying mitotane-induced mitochondria-associated membranes dysfunctions: met." *Oncotarget*, 2017. PMID: [29299119](https://pubmed.ncbi.nlm.nih.gov/29299119/)

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  <img src="" alt="Metabolomic profiling of adrenocortical carcinoma cells treated with mitotane, revealing significant alterations in mitochondrial metabolite concentrations. The drug concentrates in mitochondria and disrupts normal metabolic function." />
  <figcaption>Figure 1. Metabolomic profiling of adrenocortical carcinoma cells treated with mitotane, revealing significant alterations in mitochondrial metabolite concentrations. The drug concentrates in mitochondria and disrupts normal metabolic function.<br>  Source: Ségolène Hescot et al. "Identifying mitotane-induced mitochondria-associated membranes dysfunctions: met." <em>Oncotarget</em>, 2017. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29299119/">29299119</a></figcaption>
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