What is the recommended dosage for Folate?

General: 400 mcg DFE/day (RDA); Cognitive Support: 400-800 mcg/day

What are the side effects of Folate?

Potential side effects include: Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses.

Folate (vitamin B9) is an essential B vitamin involved in DNA synthesis, methylation reactions, and neurotransmitter production. Adequate folate status is important for brain health, and deficiency has been associated with elevated homocysteine levels and cognitive concerns in older adults.

What dosage of Folate has been used in cognitive studies?

Cognitive studies have used 400 mcg to 800 mcg of folate daily, often in the methylfolate (5-MTHF) form for better bioavailability. Some studies have combined folate with vitamin B12 and B6. The tolerable upper intake for synthetic folic acid is 1,000 mcg per day. Consult your doctor.

What are the potential side effects of Folate?

Folate from food and methylfolate supplements is generally safe. High-dose folic acid (the synthetic form) may mask vitamin B12 deficiency symptoms and has been studied for potential concerns at very high intakes. Consult your healthcare provider for appropriate dosing.

Folate
Folate

vitamin

다른 이름: Vitamin B9, Folic Acid, 5-MTHF, Methylfolate, L-Methylfolate

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About

Folate is a critical cofactor in the homocysteine-methionine cycle, supporting SAM production essential for neurotransmitter synthesis and DNA methylation. Combined with B12, folate supplementation slowed brain atrophy rate in MCI patients.

How It Works

Critical cofactor in the homocysteine-methionine cycle; supports SAM production essential for neurotransmitter synthesis and DNA methylation; deficiency leads to elevated homocysteine associated with cerebral damage.

Evidence For Conditions

건강 상태	등급	연구	참여자
Nutritional Deficiency Cognitive Impairment	B	10	1500	보기 →

Side Effects

Generally well-tolerated
May mask B12 deficiency symptoms
Rare: insomnia or irritability at high doses

Drug & Supplement Interactions

Methotrexate (antagonist — folate reduces efficacy)
Anticonvulsants (phenytoin, carbamazepine — mutual interference)
Sulfasalazine (reduces folate absorption)

복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.

Related Ingredients

Vitamin D Vitamin B6 Vitamin E Niacin Vitamin B12

핵심 정보

용량: General: 400 mcg DFE/day (RDA); Cognitive_Support: 400-800 mcg/day
제형: capsule tablet
천연 원료: Dark leafy greens, Legumes, Liver, Fortified grains, Asparagus
상한 섭취량: 1,000 mcg/day from supplements (may mask B12 deficiency)
권장 복용 시간: With or without food; morning preferred

근거 요약

Nutritional Deficiency Cognitive Impairment B

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.