Folate 관련 영양 결핍성 인지 장애
B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
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B
결론
Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs: None
Outcome: Cognitive impairment risk
효과: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
대상 집단: Elderly participants aged 60+ from NHANES 2011-2014
Cross-Sectional Study
n=1966
Folate mediates cognitive impairment of aged people with periodontitis.
Dose: None
vs: Placebo
효과: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1%
None
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
vs: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
효과: None
None
대상 집단: Pregnant women (review)
Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None
vs: Standard care or placebo
Outcome: Global cognition in stroke survivors
효과: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins)
0.009 (protein); 0.02 (B-vit)
대상 집단: Adult stroke survivors (20 trials + 14 observational)
Other
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Dose: None
vs: None
Outcome: Causal association of micronutrients with RLS
효과: Retinol OR 0.46; Mg OR 0.62
None
대상 집단: European ancestry (7248 RLS cases, 19802 controls)
Randomized Controlled Trial
Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented)
vs: Within-trial comparison
Outcome: B12/homocysteine association with PD outcomes
효과: None
None
대상 집단: Early Parkinson's disease patients
Key Statistics
10
연구
1500
참여자
↑
Positive
B
등급
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 인용
Nutritional neuroscience
2025
1 인용
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Meta-Analysis
Advances in nutrition …
2025
1 인용
Food science & …
2025
Food and nutrition …
2024
19 인용
European journal of …
2024
16 인용
Journal of Parkinson's …
2024
1 인용
Nutrients
2023
9 인용
Clinical nutrition ESPEN
2023
5 인용
The British journal …
2022
7 인용
The Permanente journal
2022
Nutrition and health
2021
13 인용
The Senior care …
2021
2 인용
Systematic reviews
2020
29 인용
Journal of Alzheimer's …
2018
281 인용
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 인용
The journal of …
2017
75 인용
Nutrients
2016
114 인용
The journal of …
2015
25 인용
Ginekologia polska
2015
7 인용
Ontario health technology …
2013
European journal of …
2012
225 인용
Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials.
Systematic Review
Archives of internal …
2007
222 인용
Evidence report/technology assessment
2006
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 인용
Current opinion in …
1998
30 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 400 mcg DFE/day (RDA)
- cognitivesupport:
- 400-800 mcg/day
상한량: 1,000 mcg/day from supplements (may mask B12 deficiency)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | 1966 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| None | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
권장 복용 시간: With or without food; morning preferred
Safety & Side Effects
보고된 부작용
- ⚠ Generally well-tolerated
- ⚠ May mask B12 deficiency symptoms
- ⚠ Rare: insomnia or irritability at high doses
알려진 상호작용
- ● Methotrexate (antagonist — folate reduces efficacy)
- ● Anticonvulsants (phenytoin, carbamazepine — mutual interference)
- ● Sulfasalazine (reduces folate absorption)
일일 최대 섭취 허용량: 1,000 mcg/day from supplements (may mask B12 deficiency)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Folate help with 영양 결핍성 인지 장애?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support 영양 결핍성 인지 장애 management. Our evidence grade is B (Good Evidence).
How much Folate should I take for 영양 결핍성 인지 장애?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate?
Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate and 영양 결핍성 인지 장애?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: 영양 결핍성 인지 장애
References
- [1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Fei Liu et al.. Nutr Neurosci. 2025. Folate mediates cognitive impairment of aged people with periodontitis. doi:10.1080/1028415X.2025.2536038 PubMed
- [4] Sasan Amanat et al.. Adv Nutr. 2025. Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. doi:10.1016/j.advnut.2025.100440 PubMed
- [5] Yun Lin et al.. Food Sci Nutr. 2025. Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. doi:10.1002/fsn3.70568 PubMed
- [6] Joshua W Miller et al.. Food Nutr Bull. 2024. Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications? doi:10.1177/03795721241229503 PubMed
- [7] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
- [8] Chadwick W Christine et al.. J Parkinsons Dis. 2024. Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials. doi:10.3233/JPD-240035 PubMed
- [9] Sapna Virdi et al.. Nutrients. 2023. The Role of One-Carbon Metabolism in Healthy Brain Aging. doi:10.3390/nu15183891 PubMed
- [10] Cecília Zanin Palchetti et al.. Clin Nutr ESPEN. 2023. Dietary folate intake and its association with longitudinal changes in cognition function. doi:10.1016/j.clnesp.2023.04.013 PubMed
- [11] Taeko Suzuki et al.. Br J Nutr. 2022. Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … doi:10.1017/S000711452200037X PubMed
- [12] Monica Elisabeth Winnubst et al.. Perm J. 2022. Decreasing the Symptoms of Essential Tremor With Medical Painting Therapy. doi:10.7812/TPP/20.260 PubMed
- [13] Arefeh Abbaszadeh et al.. Nutr Health. 2021. Impact of a Nordic diet on psychological function in young students. doi:10.1177/0260106020964981 PubMed
- [14] Brittany R Block et al.. Sr Care Pharm. 2021. Online Promotion of "Brain Health" Supplements. doi:10.4140/TCP.n.2021.489 PubMed
- [15] Annika Behrens et al.. Syst Rev. 2020. Vitamin B-Can it prevent cognitive decline? A systematic review and meta-analysis. doi:10.1186/s13643-020-01378-7 PubMed
- [16] A David Smith et al.. J Alzheimers Dis. 2018. Homocysteine and Dementia: An International Consensus Statement. doi:10.3233/JAD-171042 PubMed
- [17] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [18] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [19] Kirsty Porter et al.. Nutrients. 2016. Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. doi:10.3390/nu8110725 PubMed
- [20] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [21] Krzysztof Drews. Ginekol Pol. 2015. [Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. doi:10.17772/gp/60561 PubMed
- [22] Health Quality Ontario. Ont Health Technol Assess Ser. 2013. Vitamin B12 and cognitive function: an evidence-based analysis. PubMed
- [23] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [24] Ethan M Balk et al.. Arch Intern Med. 2007. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. doi:10.1001/archinte.167.1.21 PubMed
- [25] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
- [26] M Malouf et al.. Cochrane Database Syst Rev. 2003. Folic acid with or without vitamin B12 for cognition and dementia. doi:10.1002/14651858.CD004514 PubMed
- [27] W J Riedel et al.. Curr Opin Clin Nutr Metab Care. 1998. Nutrients, age and cognitive function. doi:10.1097/00075197-199811000-00017 PubMed
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