Folate ： Nutritional Deficiency Cognitive Impairment
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
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B
結論
Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs: None
Outcome: Cognitive impairment risk
効果: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
対象集団: Elderly participants aged 60+ from NHANES 2011-2014
Cross-Sectional Study
n=1966
Folate mediates cognitive impairment of aged people with periodontitis.
Dose: None
vs: Placebo
効果: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1%
None
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
vs: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
効果: None
None
対象集団: Pregnant women (review)
Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None
vs: Standard care or placebo
Outcome: Global cognition in stroke survivors
効果: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins)
0.009 (protein); 0.02 (B-vit)
対象集団: Adult stroke survivors (20 trials + 14 observational)
Other
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Dose: None
vs: None
Outcome: Causal association of micronutrients with RLS
効果: Retinol OR 0.46; Mg OR 0.62
None
対象集団: European ancestry (7248 RLS cases, 19802 controls)
Randomized Controlled Trial
Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented)
vs: Within-trial comparison
Outcome: B12/homocysteine association with PD outcomes
効果: None
None
対象集団: Early Parkinson's disease patients
Key Statistics
10
研究数
1500
参加者数
↑
Positive
B
グレード
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 件の引用
Nutritional neuroscience
2025
1 件の引用
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Meta-Analysis
Advances in nutrition …
2025
1 件の引用
Food science & …
2025
Food and nutrition …
2024
19 件の引用
European journal of …
2024
16 件の引用
Journal of Parkinson's …
2024
1 件の引用
Nutrients
2023
9 件の引用
Clinical nutrition ESPEN
2023
5 件の引用
The British journal …
2022
7 件の引用
The Permanente journal
2022
Nutrition and health
2021
13 件の引用
The Senior care …
2021
2 件の引用
Systematic reviews
2020
29 件の引用
Journal of Alzheimer's …
2018
281 件の引用
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 件の引用
The journal of …
2017
75 件の引用
Nutrients
2016
114 件の引用
The journal of …
2015
25 件の引用
Ginekologia polska
2015
7 件の引用
Ontario health technology …
2013
European journal of …
2012
225 件の引用
Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials.
Systematic Review
Archives of internal …
2007
222 件の引用
Evidence report/technology assessment
2006
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 件の引用
Current opinion in …
1998
30 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 400 mcg DFE/day (RDA)
- cognitivesupport:
- 400-800 mcg/day
上限量： 1,000 mcg/day from supplements (may mask B12 deficiency)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | 1966 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| None | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
推奨摂取タイミング： With or without food; morning preferred
Safety & Side Effects
報告されている副作用
- ⚠ Generally well-tolerated
- ⚠ May mask B12 deficiency symptoms
- ⚠ Rare: insomnia or irritability at high doses
既知の相互作用
- ● Methotrexate (antagonist — folate reduces efficacy)
- ● Anticonvulsants (phenytoin, carbamazepine — mutual interference)
- ● Sulfasalazine (reduces folate absorption)
耐容上限摂取量： 1,000 mcg/day from supplements (may mask B12 deficiency)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Folate help with Nutritional Deficiency Cognitive Impairment?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).
How much Folate should I take for Nutritional Deficiency Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate?
Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate and Nutritional Deficiency Cognitive Impairment?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Nutritional Deficiency Cognitive Impairment
References
- [1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Fei Liu et al.. Nutr Neurosci. 2025. Folate mediates cognitive impairment of aged people with periodontitis. doi:10.1080/1028415X.2025.2536038 PubMed
- [4] Sasan Amanat et al.. Adv Nutr. 2025. Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. doi:10.1016/j.advnut.2025.100440 PubMed
- [5] Yun Lin et al.. Food Sci Nutr. 2025. Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. doi:10.1002/fsn3.70568 PubMed
- [6] Joshua W Miller et al.. Food Nutr Bull. 2024. Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications? doi:10.1177/03795721241229503 PubMed
- [7] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
- [8] Chadwick W Christine et al.. J Parkinsons Dis. 2024. Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials. doi:10.3233/JPD-240035 PubMed
- [9] Sapna Virdi et al.. Nutrients. 2023. The Role of One-Carbon Metabolism in Healthy Brain Aging. doi:10.3390/nu15183891 PubMed
- [10] Cecília Zanin Palchetti et al.. Clin Nutr ESPEN. 2023. Dietary folate intake and its association with longitudinal changes in cognition function. doi:10.1016/j.clnesp.2023.04.013 PubMed
- [11] Taeko Suzuki et al.. Br J Nutr. 2022. Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … doi:10.1017/S000711452200037X PubMed
- [12] Monica Elisabeth Winnubst et al.. Perm J. 2022. Decreasing the Symptoms of Essential Tremor With Medical Painting Therapy. doi:10.7812/TPP/20.260 PubMed
- [13] Arefeh Abbaszadeh et al.. Nutr Health. 2021. Impact of a Nordic diet on psychological function in young students. doi:10.1177/0260106020964981 PubMed
- [14] Brittany R Block et al.. Sr Care Pharm. 2021. Online Promotion of "Brain Health" Supplements. doi:10.4140/TCP.n.2021.489 PubMed
- [15] Annika Behrens et al.. Syst Rev. 2020. Vitamin B-Can it prevent cognitive decline? A systematic review and meta-analysis. doi:10.1186/s13643-020-01378-7 PubMed
- [16] A David Smith et al.. J Alzheimers Dis. 2018. Homocysteine and Dementia: An International Consensus Statement. doi:10.3233/JAD-171042 PubMed
- [17] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [18] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [19] Kirsty Porter et al.. Nutrients. 2016. Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. doi:10.3390/nu8110725 PubMed
- [20] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [21] Krzysztof Drews. Ginekol Pol. 2015. [Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. doi:10.17772/gp/60561 PubMed
- [22] Health Quality Ontario. Ont Health Technol Assess Ser. 2013. Vitamin B12 and cognitive function: an evidence-based analysis. PubMed
- [23] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [24] Ethan M Balk et al.. Arch Intern Med. 2007. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. doi:10.1001/archinte.167.1.21 PubMed
- [25] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
- [26] M Malouf et al.. Cochrane Database Syst Rev. 2003. Folic acid with or without vitamin B12 for cognition and dementia. doi:10.1002/14651858.CD004514 PubMed
- [27] W J Riedel et al.. Curr Opin Clin Nutr Metab Care. 1998. Nutrients, age and cognitive function. doi:10.1097/00075197-199811000-00017 PubMed
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