Vitamin D ： Nutritional Deficiency Cognitive Impairment
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Vitamin D deficiency is identified as a critical risk factor for cognitive decline. 40% of geriatric memory clinic patients are D-deficient. Co-supplementation with B12 and folate appears to provide synergistic cognitive support.
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B
結論
Vitamin D deficiency is identified as a critical risk factor for cognitive decline. 40% of geriatric memory clinic patients are D-deficient. Co-supplementation with B12 and folate appears to provide synergistic cognitive support.
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs: None
Outcome: Cognitive impairment risk
効果: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
対象集団: Elderly participants aged 60+ from NHANES 2011-2014
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
vs: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
効果: None
None
対象集団: Pregnant women (review)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
vs: Control
Outcome: Cognitive function
効果: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
対象集団: Patients with mild cognitive impairment
Other
Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis.
Dose: 75 mg
vs: None
Outcome: Body weight
効果: None
P < 0.05
対象集団: Rat model
Controlled Clinical Trial
Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.
Dose: None
vs: None
Outcome: neuroprotection
効果: None
None
対象集団: None
RCT
n=65
36 weeks
Double-blind
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: …
Dose: 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi
vs: Placebo
効果: significant improvement in cognitive fatigue (FIS-40); p = 0.0338
0.0338
Key Statistics
20
研究数
4500
参加者数
↑
Positive
B
グレード
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 件の引用
European journal of …
2024
16 件の引用
Poultry science
2024
9 件の引用
Nutrients
2023
9 件の引用
Frontiers in neuroscience
2023
5 件の引用
Journal of cosmetic …
2023
3 件の引用
Nutrition and health
2020
4 件の引用
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 件の引用
The journal of …
2017
75 件の引用
The journal of …
2015
25 件の引用
[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].
Review
Der Internist
2015
3 件の引用
European journal of …
2012
225 件の引用
Evidence report/technology assessment
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 600-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day
上限量： 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 75 mg | -- | Neutral | -- |
| None | -- | Positive | -- |
| 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi | 36 weeks | Positive | 65 |
| None | -- | Negative | 90 |
| 50000 IU/week | 9 weeks | Positive | 619 |
推奨摂取タイミング： With meals containing fat; morning preferred
Safety & Side Effects
報告されている副作用
- ⚠ Hypercalcemia at very high doses
- ⚠ Nausea and vomiting
- ⚠ Kidney stones (rare, high doses)
- ⚠ Weakness and fatigue
既知の相互作用
- ● Corticosteroids (reduce calcium absorption)
- ● Statins (both affect cholesterol pathways)
- ● Thiazide diuretics (additive calcium retention)
- ● Weight loss drugs (may reduce vitamin D absorption)
耐容上限摂取量： 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Vitamin D help with Nutritional Deficiency Cognitive Impairment?
Based on 20 studies with 4,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for Nutritional Deficiency Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Nutritional Deficiency Cognitive Impairment?
We rate the evidence as Grade B (Good Evidence). This rating is based on 20 peer-reviewed studies with 4,500 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Nutritional Deficiency Cognitive Impairment
Vitamin D 他の症状・状態について
References
- [1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
- [4] Guangtian Cao et al.. Poult Sci. 2024. Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. doi:10.1016/j.psj.2024.103966 PubMed
- [5] Marcos Lacasa et al.. Nutrients. 2023. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.3390/nu15214504 PubMed
- [6] Nijee S Luthra et al.. Front Neurosci. 2023. Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. doi:10.3389/fnins.2023.1228444 PubMed
- [7] N M Dawoud et al.. J Cosmet Dermatol. 2023. Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … doi:10.1111/jocd.15725 PubMed
- [8] Elahe Allahyari et al.. Nutr Health. 2020. The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. doi:10.1177/0260106020937190 PubMed
- [9] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [10] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [11] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [12] D Polivka et al.. Internist (Berl). 2015. [Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. doi:10.1007/s00108-015-3778-9 PubMed
- [13] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [14] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
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