Vitamin D für Nutritional Deficiency Cognitive Impairment
B Evidenz Mindestens eine randomisierte Studie unterstützt dies, mit überwiegend konsistenten Ergebnissen.Vitamin D deficiency is identified as a critical risk factor for cognitive decline. 40% of geriatric memory clinic patients are D-deficient. Co-supplementation with B12 and folate appears to provide synergistic cognitive support.
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B
Fazit
Vitamin D deficiency is identified as a critical risk factor for cognitive decline. 40% of geriatric memory clinic patients are D-deficient. Co-supplementation with B12 and folate appears to provide synergistic cognitive support.
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs.: None
Outcome: Cognitive impairment risk
Wirkung: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
Population: Elderly participants aged 60+ from NHANES 2011-2014
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
vs.: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
Wirkung: None
None
Population: Pregnant women (review)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
vs.: Control
Outcome: Cognitive function
Wirkung: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
Population: Patients with mild cognitive impairment
Other
Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis.
Dose: 75 mg
vs.: None
Outcome: Body weight
Wirkung: None
P < 0.05
Population: Rat model
Controlled Clinical Trial
Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.
Dose: None
vs.: None
Outcome: neuroprotection
Wirkung: None
None
Population: None
RCT
n=65
36 weeks
Double-blind
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: …
Dose: 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi
vs.: Placebo
Wirkung: significant improvement in cognitive fatigue (FIS-40); p = 0.0338
0.0338
Key Statistics
20
Studien
4500
Teilnehmer
↑
Positive
B
Bewertung
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 Zitierungen
European journal of …
2024
16 Zitierungen
Poultry science
2024
9 Zitierungen
Nutrients
2023
9 Zitierungen
Frontiers in neuroscience
2023
5 Zitierungen
Journal of cosmetic …
2023
3 Zitierungen
Nutrition and health
2020
4 Zitierungen
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 Zitierungen
The journal of …
2017
75 Zitierungen
The journal of …
2015
25 Zitierungen
[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].
Review
Der Internist
2015
3 Zitierungen
European journal of …
2012
225 Zitierungen
Evidence report/technology assessment
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- general:
- 600-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day
Obergrenze: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 75 mg | -- | Neutral | -- |
| None | -- | Positive | -- |
| 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi | 36 weeks | Positive | 65 |
| None | -- | Negative | 90 |
| 50000 IU/week | 9 weeks | Positive | 619 |
Beste Einnahmezeit: With meals containing fat; morning preferred
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ Hypercalcemia at very high doses
- ⚠ Nausea and vomiting
- ⚠ Kidney stones (rare, high doses)
- ⚠ Weakness and fatigue
Bekannte Wechselwirkungen
- ● Corticosteroids (reduce calcium absorption)
- ● Statins (both affect cholesterol pathways)
- ● Thiazide diuretics (additive calcium retention)
- ● Weight loss drugs (may reduce vitamin D absorption)
Tolerierbare Höchstaufnahmemenge: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Vitamin D help with Nutritional Deficiency Cognitive Impairment?
Based on 20 studies with 4,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for Nutritional Deficiency Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Nutritional Deficiency Cognitive Impairment?
We rate the evidence as Grade B (Good Evidence). This rating is based on 20 peer-reviewed studies with 4,500 total participants. The overall direction of effect is positive.
Related Evidence
Andere Inhaltsstoffe für Nutritional Deficiency Cognitive Impairment
Vitamin D für andere Beschwerden
References
- [1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
- [4] Guangtian Cao et al.. Poult Sci. 2024. Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. doi:10.1016/j.psj.2024.103966 PubMed
- [5] Marcos Lacasa et al.. Nutrients. 2023. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.3390/nu15214504 PubMed
- [6] Nijee S Luthra et al.. Front Neurosci. 2023. Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. doi:10.3389/fnins.2023.1228444 PubMed
- [7] N M Dawoud et al.. J Cosmet Dermatol. 2023. Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … doi:10.1111/jocd.15725 PubMed
- [8] Elahe Allahyari et al.. Nutr Health. 2020. The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. doi:10.1177/0260106020937190 PubMed
- [9] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [10] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [11] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [12] D Polivka et al.. Internist (Berl). 2015. [Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. doi:10.1007/s00108-015-3778-9 PubMed
- [13] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [14] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
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