Folate per Nutritional Deficiency Cognitive Impairment
B Evidenze Almeno un trial randomizzato lo supporta, con risultati per lo più coerenti.Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
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B
In sintesi
Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs: None
Outcome: Cognitive impairment risk
Effetto: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
Popolazione: Elderly participants aged 60+ from NHANES 2011-2014
Cross-Sectional Study
n=1966
Folate mediates cognitive impairment of aged people with periodontitis.
Dose: None
vs: Placebo
Effetto: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1%
None
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
vs: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
Effetto: None
None
Popolazione: Pregnant women (review)
Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None
vs: Standard care or placebo
Outcome: Global cognition in stroke survivors
Effetto: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins)
0.009 (protein); 0.02 (B-vit)
Popolazione: Adult stroke survivors (20 trials + 14 observational)
Other
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Dose: None
vs: None
Outcome: Causal association of micronutrients with RLS
Effetto: Retinol OR 0.46; Mg OR 0.62
None
Popolazione: European ancestry (7248 RLS cases, 19802 controls)
Randomized Controlled Trial
Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented)
vs: Within-trial comparison
Outcome: B12/homocysteine association with PD outcomes
Effetto: None
None
Popolazione: Early Parkinson's disease patients
Key Statistics
10
Studi
1500
Partecipanti
↑
Positive
B
Grado
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 citazioni
Nutritional neuroscience
2025
1 citazioni
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Meta-Analysis
Advances in nutrition …
2025
1 citazioni
Food science & …
2025
Food and nutrition …
2024
19 citazioni
European journal of …
2024
16 citazioni
Journal of Parkinson's …
2024
1 citazioni
Nutrients
2023
9 citazioni
Clinical nutrition ESPEN
2023
5 citazioni
The British journal …
2022
7 citazioni
The Permanente journal
2022
Nutrition and health
2021
13 citazioni
The Senior care …
2021
2 citazioni
Systematic reviews
2020
29 citazioni
Journal of Alzheimer's …
2018
281 citazioni
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 citazioni
The journal of …
2017
75 citazioni
Nutrients
2016
114 citazioni
The journal of …
2015
25 citazioni
Ginekologia polska
2015
7 citazioni
Ontario health technology …
2013
European journal of …
2012
225 citazioni
Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials.
Systematic Review
Archives of internal …
2007
222 citazioni
Evidence report/technology assessment
2006
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 citazioni
Current opinion in …
1998
30 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 400 mcg DFE/day (RDA)
- cognitivesupport:
- 400-800 mcg/day
Limite massimo: 1,000 mcg/day from supplements (may mask B12 deficiency)
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | 1966 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| None | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
Momento migliore per l'assunzione: With or without food; morning preferred
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Generally well-tolerated
- ⚠ May mask B12 deficiency symptoms
- ⚠ Rare: insomnia or irritability at high doses
Interazioni note
- ● Methotrexate (antagonist — folate reduces efficacy)
- ● Anticonvulsants (phenytoin, carbamazepine — mutual interference)
- ● Sulfasalazine (reduces folate absorption)
Livello di assunzione massimo tollerabile: 1,000 mcg/day from supplements (may mask B12 deficiency)
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Folate help with Nutritional Deficiency Cognitive Impairment?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).
How much Folate should I take for Nutritional Deficiency Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate?
Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate and Nutritional Deficiency Cognitive Impairment?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Nutritional Deficiency Cognitive Impairment
References
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- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Fei Liu et al.. Nutr Neurosci. 2025. Folate mediates cognitive impairment of aged people with periodontitis. doi:10.1080/1028415X.2025.2536038 PubMed
- [4] Sasan Amanat et al.. Adv Nutr. 2025. Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. doi:10.1016/j.advnut.2025.100440 PubMed
- [5] Yun Lin et al.. Food Sci Nutr. 2025. Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. doi:10.1002/fsn3.70568 PubMed
- [6] Joshua W Miller et al.. Food Nutr Bull. 2024. Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications? doi:10.1177/03795721241229503 PubMed
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- [17] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [18] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [19] Kirsty Porter et al.. Nutrients. 2016. Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. doi:10.3390/nu8110725 PubMed
- [20] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [21] Krzysztof Drews. Ginekol Pol. 2015. [Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. doi:10.17772/gp/60561 PubMed
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- [23] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [24] Ethan M Balk et al.. Arch Intern Med. 2007. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. doi:10.1001/archinte.167.1.21 PubMed
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