Melatonin has multiorgan effects.

Lionel H Opie, Sandrine Lecour

Review European heart journal. Cardiovascular pharmacotherapy 2016 77 citations

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Study Design

Study Type: Review
Population: General population (melatonin multiorgan effects)

Intervention: Melatonin has multiorgan effects. None
Comparator: None
Primary Outcome: None
Effect Direction: Mixed
Risk of Bias: Unclear

Abstract

Melatonin, widely used to counter transatlantic travel jet lag and insomnia, is synthesized in the suprachiasmatic nucleus of the anterior pituitary gland. Its release into the circulation is stimulated by the onset of darkness, followed by a progressive decrease in blood levels with the onset of dawn. Melatonin administration can maintain the quality of sleep and help to counteract age-induced cognitive decline. Melatonin can also limit the severity of a variety of cardiovascular and cerebrovascular diseases, diabetes, and cancer.

TL;DR

Melatonin administration can maintain the quality of sleep and help to counteract age-induced cognitive decline, and limit the severity of a variety of cardiovascular and cerebrovascular diseases, diabetes, and cancer.

Used In Evidence Reviews

C Melatonin for Sleep-Related Cognitive Impairment

Melatonin has multiorgan effects.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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