Descrição

The amyloid cascade hypothesis and its therapeutic targets are illustrated, showing how beta-secretase and gamma-secretase inhibitors, along with anti-amyloid antibodies, aim to reduce pathological plaque formation.

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Figure 1

Major pharmacotherapeutic targets in Alzheimer's disease are mapped, including amyloid-beta aggregation, tau hyperphosphorylation, neuroinflammation, and cholinergic dysfunction as key intervention points.

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Figure 3

Tau protein pathology and potential therapeutic interventions are depicted, including kinase inhibitors and immunotherapy approaches targeting neurofibrillary tangle formation in Alzheimer's disease.

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Figure 4

Neuroinflammatory pathways in Alzheimer's disease and anti-inflammatory therapeutic targets are outlined, showing microglial activation, cytokine cascades, and potential points of pharmacological intervention.

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Figure 5

Traditional medicinal plants investigated for Alzheimer's management are catalogued with their bioactive compounds and proposed neuroprotective mechanisms, including antioxidant and anti-inflammatory activities.

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Figure 6

Cholinergic system dysfunction in Alzheimer's disease and current cholinesterase inhibitor therapies are illustrated, showing how acetylcholine deficiency contributes to cognitive decline.

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Figure 2

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Source Paper

Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants.

Degenerative neurological and neuromuscular disease (2024)

PMID: 38784601

DOI: 10.2147/DNND.S452009

Cite This Figure

![Figure 2: The amyloid cascade hypothesis and its therapeutic targets are illustrated, showing how beta-secretase and gamma-secretase inhibitors, along with anti-amyloid antibodies, aim to reduce pathological plaque formation.](https://pdfs.citedhealth.com/figures/38784601/521.png)

> Source: Prabhash Nath Tripathi et al. "Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management ." *Degenerative neurological and neuromuscular disease*, 2024. PMID: [38784601](https://pubmed.ncbi.nlm.nih.gov/38784601/)

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  <img src="https://pdfs.citedhealth.com/figures/38784601/521.png" alt="The amyloid cascade hypothesis and its therapeutic targets are illustrated, showing how beta-secretase and gamma-secretase inhibitors, along with anti-amyloid antibodies, aim to reduce pathological plaque formation." />
  <figcaption>Figure 2. The amyloid cascade hypothesis and its therapeutic targets are illustrated, showing how beta-secretase and gamma-secretase inhibitors, along with anti-amyloid antibodies, aim to reduce pathological plaque formation.<br>  Source: Prabhash Nath Tripathi et al. "Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management ." <em>Degenerative neurological and neuromuscular disease</em>, 2024. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38784601/">38784601</a></figcaption>
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