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Schematic overview of the mitochondrial permeability transition pore (mPTP) and how age-related changes in its regulation contribute to cytochrome c release and apoptotic cell death in hippocampal neurons.

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![Figure 20: Schematic overview of the mitochondrial permeability transition pore (mPTP) and how age-related changes in its regulation contribute to cytochrome c release and apoptotic cell death in hippocampal neurons.]()

> Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." *Oxidative medicine and cellular longevity*, 2019. PMID: [31214285](https://pubmed.ncbi.nlm.nih.gov/31214285/)
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  <img src="" alt="Schematic overview of the mitochondrial permeability transition pore (mPTP) and how age-related changes in its regulation contribute to cytochrome c release and apoptotic cell death in hippocampal neurons." />
  <figcaption>Figure 20. Schematic overview of the mitochondrial permeability transition pore (mPTP) and how age-related changes in its regulation contribute to cytochrome c release and apoptotic cell death in hippocampal neurons.<br>  Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." <em>Oxidative medicine and cellular longevity</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31214285/">31214285</a></figcaption>
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