Ginkgo biloba cho Age-Related Cognitive Decline
C Bằng chứng Bằng chứng hạn chế từ các nghiên cứu nhỏ, nhưng có một số tín hiệu tích cực.The most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.
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C
Kết luận
The most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.
Key Study Findings
Review
EGb761 Trials for Mild-to-Moderate Dementia-What Have We Learned in the Past 18 years?
Dose: None
so với: placebo
Outcome: cognitive assessment scores (MMSE, SKT, NPI)
Hiệu quả: None
None
Đối tượng nghiên cứu: patients with mild-to-moderate Alzheimer disease or vascular dementia
Review
Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: patients with vascular cognitive impairment and dementia
Review
Nutritional strategies against dementia in rural populations.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: Rural populations with dementia risk
Cohort Study
n=64
52 weeks
Open-label
Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment.
Dose: 240 mg/day
so với: Standard cognitive enhancers
Outcome: Cognitive responder rate and AD conversion
Hiệu quả: 100% vs 59.1% responders; 0% vs 13.6% AD conversio
<0.001 (responders); 0.037 (AD
Đối tượng nghiên cứu: Amyloid PET-positive MCI patients
Review
Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review.
Dose: None
so với: None
Outcome: Cognitive function in multiple sclerosis
Hiệu quả: None
None
Đối tượng nghiên cứu: Multiple sclerosis patients (review)
Other
Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 …
Dose: None
so với: BCAS model mice without GBE50
Outcome: Cognitive impairment and white matter lesions
Hiệu quả: None
None
Đối tượng nghiên cứu: BCAS cerebral small vessel disease mouse model
Key Statistics
40
Nghiên cứu
8000
Người tham gia
↔
Mixed
C
Xếp hạng
Referenced Papers
American journal of …
None
1 trích dẫn
Neuropsychopharmacology : official …
2026
1 trích dẫn
Journal of ethnopharmacology
2025
5 trích dẫn
Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment.
Other
Frontiers in neurology
2025
4 trích dẫn
Annals of medicine …
2025
3 trích dẫn
Handbook of experimental …
2025
1 trích dẫn
Frontiers in nutrition
2025
Degenerative neurological and …
2024
66 trích dẫn
Journal of Alzheimer's …
2024
12 trích dẫn
Current Alzheimer research
2024
10 trích dẫn
Dementia and geriatric …
2024
6 trích dẫn
Medicine
2024
3 trích dẫn
Food science & …
2024
3 trích dẫn
Biology
2023
37 trích dẫn
Scientific reports
2023
30 trích dẫn
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with …
Systematic Review
Systematic reviews
2023
10 trích dẫn
Biomolecules
2021
161 trích dẫn
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 trích dẫn
Pharmaceuticals (Basel, Switzerland)
2021
33 trích dẫn
The Effect of Polyphenols on Working and Episodic Memory in Non-pathological and Pathological Aging: A Systematic Review and Meta-Analysis.
Systematic Review
Frontiers in nutrition
2021
26 trích dẫn
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
Systematic Review
Journal of alternative …
2021
13 trích dẫn
CNS & neurological …
2021
12 trích dẫn
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
2020
4 trích dẫn
Oxidative medicine and …
2019
102 trích dẫn
Prostaglandins, leukotrienes, and …
2019
5 trích dẫn
Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Systematic Review
Annals of internal …
2018
119 trích dẫn
Acta bio-medica : …
2018
103 trích dẫn
Pharmacological research
2018
67 trích dẫn
Frontiers in nutrition
2018
18 trích dẫn
The journals of …
2017
97 trích dẫn
Journal of Alzheimer's …
2017
17 trích dẫn
Frontiers in aging …
2016
72 trích dẫn
Nutrients
2016
53 trích dẫn
Journal of the …
2016
16 trích dẫn
The American journal …
2015
204 trích dẫn
Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.
Meta-Analysis
Climacteric : the …
2015
92 trích dẫn
Age (Dordrecht, Netherlands)
2014
Clinical pharmacokinetics
2013
220 trích dẫn
CNS drugs
2013
138 trích dẫn
Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.
Other
PloS one
2013
73 trích dẫn
International psychogeriatrics
2012
29 trích dẫn
American family physician
2011
Experimental aging research
2010
21 trích dẫn
JAMA
2010
3 trích dẫn
The Practitioner
2010
JAMA
2009
304 trích dẫn
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2009
299 trích dẫn
Epidemiologic reviews
2008
172 trích dẫn
Neurology
2008
147 trích dẫn
The Canadian veterinary …
2008
Herbal drug treatment.
Review
Neuro endocrinology letters
2008
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2007
375 trích dẫn
The Proceedings of …
2002
191 trích dẫn
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2002
Alternative medicine review …
1999
112 trích dẫn
Current opinion in …
1998
30 trích dẫn
British journal of …
1993
8 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones
Giới hạn trên: 600 mg/day (doses above show no additional benefit)
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 240 mg/day | 52 weeks | Positive | 64 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Thời điểm dùng tốt nhất: With meals; may require 4-6 weeks for full effects
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Headache
- ⚠ Gastrointestinal upset
- ⚠ Dizziness
- ⚠ Allergic skin reactions (rare)
- ⚠ Increased bleeding risk
Tương tác đã biết
- ● Anticoagulants and antiplatelet drugs (increased bleeding risk)
- ● Anticonvulsants (may reduce seizure threshold)
- ● SSRIs (serotonin syndrome risk, rare)
- ● CYP3A4 substrates (may affect drug metabolism)
Mức hấp thụ tối đa cho phép: 600 mg/day (doses above show no additional benefit)
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Ginkgo biloba help with Age-Related Cognitive Decline?
Based on 40 studies with 8,000 participants, there is limited but promising evidence that Ginkgo biloba may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Ginkgo biloba should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ginkgo biloba?
Reported side effects may include Headache, Gastrointestinal upset, Dizziness, Allergic skin reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ginkgo biloba and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 40 peer-reviewed studies with 8,000 total participants. The overall direction of effect is mixed.
Related Evidence
Các thành phần khác cho Age-Related Cognitive Decline
Ginkgo biloba cho các tình trạng khác
References
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