Ginkgo biloba için Age-Related Cognitive Decline
C Kanıt Küçük çalışmalardan sınırlı kanıt mevcuttur, ancak bazı olumlu sinyaller bulunmaktadır.The most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.
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C
Sonuç
The most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.
Key Study Findings
Review
EGb761 Trials for Mild-to-Moderate Dementia-What Have We Learned in the Past 18 years?
Dose: None
vs: placebo
Outcome: cognitive assessment scores (MMSE, SKT, NPI)
Etki: None
None
Popülasyon: patients with mild-to-moderate Alzheimer disease or vascular dementia
Review
Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: patients with vascular cognitive impairment and dementia
Review
Nutritional strategies against dementia in rural populations.
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: Rural populations with dementia risk
Cohort Study
n=64
52 weeks
Open-label
Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment.
Dose: 240 mg/day
vs: Standard cognitive enhancers
Outcome: Cognitive responder rate and AD conversion
Etki: 100% vs 59.1% responders; 0% vs 13.6% AD conversio
<0.001 (responders); 0.037 (AD
Popülasyon: Amyloid PET-positive MCI patients
Review
Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review.
Dose: None
vs: None
Outcome: Cognitive function in multiple sclerosis
Etki: None
None
Popülasyon: Multiple sclerosis patients (review)
Other
Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 …
Dose: None
vs: BCAS model mice without GBE50
Outcome: Cognitive impairment and white matter lesions
Etki: None
None
Popülasyon: BCAS cerebral small vessel disease mouse model
Key Statistics
40
Çalışmalar
8000
Katılımcılar
↔
Mixed
C
Derece
Referenced Papers
American journal of …
None
1 atıf
Neuropsychopharmacology : official …
2026
1 atıf
Journal of ethnopharmacology
2025
5 atıf
Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment.
Other
Frontiers in neurology
2025
4 atıf
Annals of medicine …
2025
3 atıf
Handbook of experimental …
2025
1 atıf
Frontiers in nutrition
2025
Degenerative neurological and …
2024
66 atıf
Journal of Alzheimer's …
2024
12 atıf
Current Alzheimer research
2024
10 atıf
Dementia and geriatric …
2024
6 atıf
Medicine
2024
3 atıf
Food science & …
2024
3 atıf
Biology
2023
37 atıf
Scientific reports
2023
30 atıf
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with …
Systematic Review
Systematic reviews
2023
10 atıf
Biomolecules
2021
161 atıf
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 atıf
Pharmaceuticals (Basel, Switzerland)
2021
33 atıf
The Effect of Polyphenols on Working and Episodic Memory in Non-pathological and Pathological Aging: A Systematic Review and Meta-Analysis.
Systematic Review
Frontiers in nutrition
2021
26 atıf
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
Systematic Review
Journal of alternative …
2021
13 atıf
CNS & neurological …
2021
12 atıf
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
2020
4 atıf
Oxidative medicine and …
2019
102 atıf
Prostaglandins, leukotrienes, and …
2019
5 atıf
Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Systematic Review
Annals of internal …
2018
119 atıf
Acta bio-medica : …
2018
103 atıf
Pharmacological research
2018
67 atıf
Frontiers in nutrition
2018
18 atıf
The journals of …
2017
97 atıf
Journal of Alzheimer's …
2017
17 atıf
Frontiers in aging …
2016
72 atıf
Nutrients
2016
53 atıf
Journal of the …
2016
16 atıf
The American journal …
2015
204 atıf
Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.
Meta-Analysis
Climacteric : the …
2015
92 atıf
Age (Dordrecht, Netherlands)
2014
Clinical pharmacokinetics
2013
220 atıf
CNS drugs
2013
138 atıf
Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.
Other
PloS one
2013
73 atıf
International psychogeriatrics
2012
29 atıf
American family physician
2011
Experimental aging research
2010
21 atıf
JAMA
2010
3 atıf
The Practitioner
2010
JAMA
2009
304 atıf
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2009
299 atıf
Epidemiologic reviews
2008
172 atıf
Neurology
2008
147 atıf
The Canadian veterinary …
2008
Herbal drug treatment.
Review
Neuro endocrinology letters
2008
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2007
375 atıf
The Proceedings of …
2002
191 atıf
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2002
Alternative medicine review …
1999
112 atıf
Current opinion in …
1998
30 atıf
British journal of …
1993
8 atıf
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- general:
- 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones
Üst sınır: 600 mg/day (doses above show no additional benefit)
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 240 mg/day | 52 weeks | Positive | 64 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
En iyi alım zamanı: With meals; may require 4-6 weeks for full effects
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Headache
- ⚠ Gastrointestinal upset
- ⚠ Dizziness
- ⚠ Allergic skin reactions (rare)
- ⚠ Increased bleeding risk
Bilinen Etkileşimler
- ● Anticoagulants and antiplatelet drugs (increased bleeding risk)
- ● Anticonvulsants (may reduce seizure threshold)
- ● SSRIs (serotonin syndrome risk, rare)
- ● CYP3A4 substrates (may affect drug metabolism)
Tolere edilebilir üst alım: 600 mg/day (doses above show no additional benefit)
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does Ginkgo biloba help with Age-Related Cognitive Decline?
Based on 40 studies with 8,000 participants, there is limited but promising evidence that Ginkgo biloba may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Ginkgo biloba should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ginkgo biloba?
Reported side effects may include Headache, Gastrointestinal upset, Dizziness, Allergic skin reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ginkgo biloba and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 40 peer-reviewed studies with 8,000 total participants. The overall direction of effect is mixed.
Related Evidence
Şu durum için diğer içerikler: Age-Related Cognitive Decline
Ginkgo biloba diğer sağlık durumları için
References
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