Omega-3 Fatty Acids (DHA/EPA) لـ Age-Related Cognitive Decline

References

1. [1] Vicente Javier Clemente-Suárez et al.. Nutrients. 2025. Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review. doi:10.3390/nu17050884 PubMed
2. [2] Rarchita Sharma et al.. Nutr Neurosci. 2025. Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection. doi:10.1080/1028415X.2025.2469170 PubMed
3. [3] Mervin Chávez-Castillo et al.. Molecules. 2025. Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer's Disease. doi:10.3390/molecules30153057 PubMed
4. [4] Paola Gualtieri et al.. Nutrients. 2025. Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease. doi:10.3390/nu17050922 PubMed
5. [5] Mehmet Kanbay et al.. Eur J Clin Invest. 2025. Nutrition, cognition and chronic kidney disease: A comprehensive review of interactions and interventions. doi:10.1111/eci.70045 PubMed
6. [6] Punyatoya Panda et al.. J Proteome Res. 2025. Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry. doi:10.1021/acs.jproteome.4c00688 PubMed
7. [7] Ali Rezaei et al.. Ann Med Surg (Lond). 2025. Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review. doi:10.1097/MS9.0000000000003124 PubMed
8. [8] Larissa Parreira Araújo et al.. Int J Mol Sci. 2025. Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. doi:10.3390/ijms262412147 PubMed
9. [9] Guilherme Christimann et al.. J Alzheimers Dis. 2025. Bioactive compounds and dietary patterns in Alzheimer's disease. doi:10.1177/13872877251319048 PubMed
10. [10] Rasha Z Alshahawy et al.. Sci Rep. 2025. Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats. doi:10.1038/s41598-025-06109-3 PubMed
11. [11] Madeleine C Nankivell et al.. Nutrients. 2025. Coenzyme Q10 and Cognition: A Review. doi:10.3390/nu17172896 PubMed
12. [12] Ozra Tabatabaei-Malazy et al.. Handb Exp Pharmacol. 2025. The Use of Natural Products for Preventing Cognitive Decline/Providing Neuroprotection. doi:10.1007/164_2024_732 PubMed
13. [13] Feng Gu et al.. Asia Pac J Clin Nutr. 2025. Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis. doi:10.6133/apjcn.202512_34(6).0007 PubMed
14. [14] Xiaopeng Li et al.. Neurochem Res. 2025. Targeting Liquid-Liquid Phase Separation and Autophagy in Alzheimer's Disease: Insights into Molecular Mechanisms and Therapeutic Potential. doi:10.1007/s11064-025-04623-4 PubMed
15. [15] Bruno S Goncalves et al.. Front Nutr. 2025. Nutritional strategies against dementia in rural populations. doi:10.3389/fnut.2025.1677197 PubMed
16. [16] Prabhash Nath Tripathi et al.. Degener Neurol Neuromuscul Dis. 2024. Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. doi:10.2147/DNND.S452009 PubMed
17. [17] JinJin Pei et al.. Ageing Res Rev. 2024. Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review. doi:10.1016/j.arr.2024.102393 PubMed
18. [18] Francine K Welty et al.. Arterioscler Thromb Vasc Biol. 2024. Fish and Omega-3 Fatty Acids: Sex and Racial Differences in Cardiovascular Outcomes and Cognitive Function. doi:10.1161/ATVBAHA.122.318125 PubMed
19. [19] Xavier Morató et al.. J Alzheimers Dis. 2024. Pharmacodynamic and Clinical Effects of Ginkgo Biloba Extract EGb 761 and Its Phytochemical Components in Alzheimer's Disease. doi:10.3233/JAD-231372 PubMed
20. [20] Ernesto Calderon Martinez et al.. Neuropsychopharmacol Rep. 2024. The effects of omega-3, DHA, EPA, Souvenaid® in Alzheimer's disease: A systematic review and meta-analysis. doi:10.1002/npr2.12455 PubMed
21. [21] Debasis Sen et al.. Curr Alzheimer Res. 2024. Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration. doi:10.2174/0115672050309057240404075003 PubMed
22. [22] Murtaza Haidary et al.. Int J Dev Neurosci. 2024. Omega-3 fatty acids supplementation prevents learning and memory impairment induced by chronic ethanol consumption in adolescent male rats through restoration … doi:10.1002/jdn.10336 PubMed
23. [23] Gaurav Vijayrao Deshmukh et al.. Cureus. 2024. The Role of Omega-3 Fatty Acid Supplementation in Slowing Cognitive Decline Among Elderly Patients With Alzheimer's Disease: A Systematic Review … doi:10.7759/cureus.73390 PubMed
24. [24] Da-Sol Kim et al.. Int J Mol Sci. 2024. Zeaxanthin and Lutein Ameliorate Alzheimer's Disease-like Pathology: Modulation of Insulin Resistance, Neuroinflammation, and Acetylcholinesterase Activity in an Amyloid-β Rat Model. doi:10.3390/ijms25189828 PubMed
25. [25] Bao-Zhen Wei et al.. Am J Clin Nutr. 2023. The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, … doi:10.1016/j.ajcnut.2023.04.001 PubMed
26. [26] Francine K Welty. Curr Opin Lipidol. 2023. Omega-3 fatty acids and cognitive function. doi:10.1097/MOL.0000000000000862 PubMed
27. [27] Ping-Tao Tseng et al.. Brain Behav Immun. 2023. Efficacy and acceptability of anti-inflammatory eicosapentaenoic acid for cognitive function in Alzheimer's dementia: A network meta-analysis of randomized, placebo-controlled trials … doi:10.1016/j.bbi.2023.04.017 PubMed
28. [28] Victoria Andrews et al.. Nutr Rev. 2023. Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews. doi:10.1093/nutrit/nuad013 PubMed
29. [29] Li Zhou et al.. Nutr Hosp. 2023. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment. doi:10.20960/nh.04394 PubMed
30. [30] Toshiaki Sueyasu et al.. Nutrients. 2023. Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults. doi:10.3390/nu15132825 PubMed
31. [31] Tiarnan D L Keenan et al.. Alzheimers Dement. 2023. Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2. doi:10.1002/alz.13033 PubMed
32. [32] Rebecca Power et al.. Clin Nutr. 2022. Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial. doi:10.1016/j.clnu.2021.12.004 PubMed
33. [33] Victoria Gil Martínez et al.. Nutrients. 2022. Vitamin Supplementation and Dementia: A Systematic Review. doi:10.3390/nu14051033 PubMed
34. [34] Pan-Yen Lin et al.. Brain Behav Immun. 2022. Omega-3 fatty acids and blood-based biomarkers in Alzheimer's disease and mild cognitive impairment: A randomized placebo-controlled trial. doi:10.1016/j.bbi.2021.10.014 PubMed
35. [35] Amy H R Wood et al.. Eur J Nutr. 2022. Dietary and supplemental long-chain omega-3 fatty acids as moderators of cognitive impairment and Alzheimer's disease. doi:10.1007/s00394-021-02655-4 PubMed
36. [36] Ignasi Mora et al.. Int J Mol Sci. 2022. Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging. doi:10.3390/ijms23073472 PubMed
37. [37] Alzbeta Katonova et al.. Int J Mol Sci. 2022. Effect of a Vegan Diet on Alzheimer's Disease. doi:10.3390/ijms232314924 PubMed
38. [38] Laure Rouch et al.. Am J Clin Nutr. 2022. Associations of erythrocyte omega-3 fatty acids with cognition, brain imaging and biomarkers in the Alzheimer's disease neuroimaging initiative: cross-sectional and … doi:10.1093/ajcn/nqac236 PubMed
39. [39] Caroline S Duchaine et al.. J Nutr. 2022. Serum ω-3 Fatty Acids and Cognitive Domains in Community-Dwelling Older Adults from the NuAge Study: Exploring the Associations with Other … doi:10.1093/jn/nxac110 PubMed
40. [40] Julie Gregory et al.. Biomolecules. 2021. Neuroprotective Herbs for the Management of Alzheimer's Disease. doi:10.3390/biom11040543 PubMed
41. [41] John E Lewis et al.. J Clin Transl Res. 2021. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. PubMed
42. [42] Cindy Crawford et al.. J Altern Complement Med. 2021. Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review. doi:10.1089/acm.2021.0135 PubMed
43. [43] Barbara Troesch et al.. Nutrients. 2020. Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition. doi:10.3390/nu12092555 PubMed
44. [44] Manuela Pennisi et al.. Nutrients. 2020. Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update. doi:10.3390/nu12051389 PubMed
45. [45] Aline Thomas et al.. Alzheimers Dement. 2020. Blood polyunsaturated omega-3 fatty acids, brain atrophy, cognitive decline, and dementia risk. doi:10.1002/alz.12195 PubMed
46. [46] Julia C Kuszewski et al.. J Nutr. 2020. Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity. doi:10.1093/jn/nxaa299 PubMed
47. [47] Kirsten M Wright et al.. Drug Metab Dispos. 2020. Centella asiatica Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions. doi:10.1124/dmd.120.090860 PubMed
48. [48] Ying-Cai Zhao et al.. Lipids Health Dis. 2020. Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat … doi:10.1186/s12944-020-01253-3 PubMed
49. [49] G C Román et al.. Rev Neurol (Paris). 2019. Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and … doi:10.1016/j.neurol.2019.08.005 PubMed
50. [50] Andrea M McGrattan et al.. Curr Nutr Rep. 2019. Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease. doi:10.1007/s13668-019-0271-4 PubMed
51. [51] Amelia Martí Del Moral et al.. Nutr Hosp. 2019. Omega-3 fatty acids and cognitive decline: a systematic review. doi:10.20960/nh.02496 PubMed
52. [52] Paul Fairbairn et al.. Prostaglandins Leukot Essent Fatty Acids. 2019. Combining a high DHA multi-nutrient supplement with aerobic exercise: Protocol for a randomised controlled study assessing mobility and cognitive function … doi:10.1016/j.plefa.2019.04.001 PubMed
53. [53] Amy Locke et al.. Am Fam Physician. 2018. Diets for Health: Goals and Guidelines. PubMed
54. [54] Arrigo F G Cicero et al.. Pharmacol Res. 2018. Botanicals and phytochemicals active on cognitive decline: The clinical evidence. doi:10.1016/j.phrs.2017.12.029 PubMed
55. [55] Rosa María Martínez García et al.. Nutr Hosp. 2018. [Nutrition strategies that improve cognitive function]. doi:10.20960/nh.2281 PubMed
56. [56] Durga Chapagain et al.. Front Psychol. 2018. Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. doi:10.3389/fpsyg.2018.02217 PubMed
57. [57] Shibu M Poulose et al.. Adv Nutr. 2017. Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function. doi:10.3945/an.117.016261 PubMed
58. [58] Luta Luse Basambombo et al.. Ann Pharmacother. 2017. Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline. doi:10.1177/1060028016673072 PubMed
59. [59] Milan Fiala et al.. FASEB J. 2017. Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids. doi:10.1096/fj.201700065R PubMed
60. [60] Tanya Gwendolyn Nock et al.. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and … doi:10.1016/j.bbalip.2017.07.004 PubMed
61. [61] Jessay Gopuran Devassy et al.. Adv Nutr. 2016. Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. doi:10.3945/an.116.012187 PubMed
62. [62] Abderrahim Oulhaj et al.. J Alzheimers Dis. 2016. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. doi:10.3233/JAD-150777 PubMed
63. [63] Katherine L Tucker. Ann N Y Acad Sci. 2016. Nutrient intake, nutritional status, and cognitive function with aging. doi:10.1111/nyas.13062 PubMed
64. [64] Xiao-Wei Zhang et al.. Aging Clin Exp Res. 2016. Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials. doi:10.1007/s40520-015-0381-9 PubMed
65. [65] Philippa A Jackson et al.. Nutrients. 2016. DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … doi:10.3390/nu8020086 PubMed
66. [66] Richa Rathod et al.. J Biomed Sci. 2016. Novel insights into the effect of vitamin B₁₂ and omega-3 fatty acids on brain function. doi:10.1186/s12929-016-0241-8 PubMed
67. [67] P Lehert et al.. Climacteric. 2015. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis. doi:10.3109/13697137.2015.1078106 PubMed
68. [68] Shengyuan Wang et al.. PLoS One. 2015. Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease. doi:10.1371/journal.pone.0143135 PubMed
69. [69] Debora Cutuli et al.. Front Aging Neurosci. 2014. n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. doi:10.3389/fnagi.2014.00220 PubMed
70. [70] Alessio Molfino et al.. Nutrients. 2014. The role for dietary omega-3 fatty acids supplementation in older adults. doi:10.3390/nu6104058 PubMed
71. [71] Ananya Sadhu et al.. Clin Drug Investig. 2014. Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product. doi:10.1007/s40261-014-0235-9 PubMed
72. [72] S Engelborghs et al.. Acta Clin Belg. 2014. Rationale and clinical data supporting nutritional intervention in Alzheimer's disease. doi:10.1179/0001551213Z.0000000006 PubMed
73. [73] Abdul-Razak Abubakari et al.. Int J Gen Med. 2014. Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial? doi:10.2147/IJGM.S67065 PubMed
74. [74] Dan L Waitzberg et al.. Nutr Hosp. 2014. [Contribution of omega-3 fatty acids for memory and cognitive function]. doi:10.3305/nh.2014.30.3.7632 PubMed
75. [75] Tommy Cederholm et al.. Adv Nutr. 2013. ω-3 fatty acids in the prevention of cognitive decline in humans. doi:10.3945/an.113.004556 PubMed
76. [76] I Denis et al.. Ageing Res Rev. 2013. Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. doi:10.1016/j.arr.2013.01.007 PubMed
77. [77] Martin Loef et al.. J Nutr Gerontol Geriatr. 2013. The omega-6/omega-3 ratio and dementia or cognitive decline: a systematic review on human studies and biological evidence. doi:10.1080/21551197.2012.752335 PubMed
78. [78] Eric M Ammann et al.. Neurology. 2013. ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA. doi:10.1212/WNL.0b013e3182a9584c PubMed
79. [79] Joann E Manson et al.. Contemp Clin Trials. 2012. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and … doi:10.1016/j.cct.2011.09.009 PubMed
80. [80] Noemí Fabelo et al.. Mol Med. 2011. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. doi:10.2119/molmed.2011.00119 PubMed
81. [81] Cécilia Samieri et al.. Neurobiol Aging. 2011. ω-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression. doi:10.1016/j.neurobiolaging.2010.03.020 PubMed
82. [82] Gene L Bowman et al.. Alzheimer Dis Assoc Disord. 2011. Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairment. doi:10.1097/WAD.0b013e3181f333d6 PubMed
83. [83] Michael J Serby et al.. Curr Treat Options Neurol. 2011. Treatment of memory loss with herbal remedies. doi:10.1007/s11940-011-0135-8 PubMed
84. [84] Sally A Frautschy et al.. Mol Neurobiol. 2010. Why pleiotropic interventions are needed for Alzheimer's disease. doi:10.1007/s12035-010-8137-1 PubMed
85. [85] Tina L Huang. J Alzheimers Dis. 2010. Omega-3 fatty acids, cognitive decline, and Alzheimer's disease: a critical review and evaluation of the literature. doi:10.3233/JAD-2010-090934 PubMed
86. [86] A Chan et al.. J Nutr Health Aging. 2010. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. doi:10.1007/s12603-010-0054-5 PubMed
87. [87] Tommy Cederholm et al.. Curr Opin Clin Nutr Metab Care. 2010. Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia? doi:10.1097/MCO.0b013e328335c40b PubMed
88. [88] Jennifer G Robinson et al.. Womens Health (Lond). 2010. Omega-3 fatty acids and cognitive function in women. doi:10.2217/whe.09.75 PubMed
89. [89] Louise A Brown et al.. Exp Aging Res. 2010. Supplementing cognitive aging: a selective review of the effects of ginkgo biloba and a number of everyday nutritional substances. doi:10.1080/03610730903417960 PubMed
90. [90] Lei Feng. JAMA. 2010. Ginkgo biloba and cognitive decline. doi:10.1001/jama.2010.434 PubMed
91. [91] Klaus P Ebmeier. Practitioner. 2010. Normal cognitive decline or dementia? PubMed
92. [92] Majid Fotuhi et al.. Nat Clin Pract Neurol. 2009. Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. doi:10.1038/ncpneuro1044 PubMed
93. [93] Beth E Snitz et al.. JAMA. 2009. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. doi:10.1001/jama.2009.1913 PubMed
94. [94] Jacqueline Birks et al.. Cochrane Database Syst Rev. 2009. Ginkgo biloba for cognitive impairment and dementia. doi:10.1002/14651858.CD003120.pub3 PubMed
95. [95] Greg M Cole et al.. Prostaglandins Leukot Essent Fatty Acids. 2009. Omega-3 fatty acids and dementia. doi:10.1016/j.plefa.2009.05.015 PubMed
96. [96] James Suchy et al.. Nutr Res. 2009. Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain … doi:10.1016/j.nutres.2008.11.004 PubMed
97. [97] Elizabeth J Johnson et al.. Nutr Neurosci. 2008. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. doi:10.1179/147683008X301450 PubMed
98. [98] Wei Wang et al.. J Alzheimers Dis. 2008. Nutritional biomarkers in Alzheimer's disease: the association between carotenoids, n-3 fatty acids, and dementia severity. doi:10.3233/jad-2008-13103 PubMed
99. [99] Marek Jarema. Neuro Endocrinol Lett. 2008. Herbal drug treatment. PubMed
100. [100] Parris M Kidd. Altern Med Rev. 2008. Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. PubMed
101. [101] J Birks et al.. Cochrane Database Syst Rev. 2007. Ginkgo biloba for cognitive impairment and dementia. doi:10.1002/14651858.CD003120.pub2 PubMed
102. [102] Parris M Kidd. Altern Med Rev. 2007. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. PubMed
103. [103] Erika Freemantle et al.. Prostaglandins Leukot Essent Fatty Acids. 2006. Omega-3 fatty acids, energy substrates, and brain function during aging. doi:10.1016/j.plefa.2006.05.011 PubMed
104. [104] J M Bourre. J Nutr Health Aging. 2005. Dietary omega-3 Fatty acids and psychiatry: mood, behaviour, stress, depression, dementia and aging. PubMed
105. [105] Jean-Marie Bourre. Med Sci (Paris). 2005. [Omega-3 fatty acids in psychiatry]. doi:10.1051/medsci/2005212216 PubMed
106. [106] M Malouf et al.. Cochrane Database Syst Rev. 2003. Folic acid with or without vitamin B12 for cognition and dementia. doi:10.1002/14651858.CD004514 PubMed
107. [107] Danielle Laurin et al.. J Alzheimers Dis. 2003. Omega-3 fatty acids and risk of cognitive impairment and dementia. doi:10.3233/jad-2003-5407 PubMed
108. [108] L A Horrocks et al.. Pharmacol Res. 1999. Health benefits of docosahexaenoic acid (DHA). doi:10.1006/phrs.1999.0495 PubMed
109. [109] P M Kidd. Altern Med Rev. 1999. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. PubMed