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Natural antidepressant compounds and their molecular targets are mapped onto neuroinflammatory signaling pathways, showing how botanical agents may modulate NF-kB, NLRP3 inflammasome, and microglial activation to produce antidepressant effects.

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![Figure 2: Natural antidepressant compounds and their molecular targets are mapped onto neuroinflammatory signaling pathways, showing how botanical agents may modulate NF-kB, NLRP3 inflammasome, and microglial activation to produce antidepressant effects.]()

> Source: Ana Clara Figueiredo Godoy et al. "Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora.." *Biomedicines*, 2025. PMID: [40426956](https://pubmed.ncbi.nlm.nih.gov/40426956/)
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  <img src="" alt="Natural antidepressant compounds and their molecular targets are mapped onto neuroinflammatory signaling pathways, showing how botanical agents may modulate NF-kB, NLRP3 inflammasome, and microglial activation to produce antidepressant effects." />
  <figcaption>Figure 2. Natural antidepressant compounds and their molecular targets are mapped onto neuroinflammatory signaling pathways, showing how botanical agents may modulate NF-kB, NLRP3 inflammasome, and microglial activation to produce antidepressant effects.<br>  Source: Ana Clara Figueiredo Godoy et al. "Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora.." <em>Biomedicines</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40426956/">40426956</a></figcaption>
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