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Melatonin für Sleep-Related Cognitive Impairment

C

Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.

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C

Fazit

Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.

Key Study Findings

review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) vs.: Placebo Wirkung: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence None
Other
Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin …
Dose: None vs.: PCPA-induced insomnia model control Outcome: Sleep quality and cognitive function in rat model Wirkung: None None

Population: PCPA-induced insomnia male rats

Randomized Controlled Trial n=322 5 weeks Double-blind
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, …
Dose: 20 mg or 50 mg tasimelteon daily vs.: Placebo Outcome: Latency to persistent sleep (PSG) Wirkung: -44.9 min (20mg) / -46.3 min (50mg) vs -28.2 (placebo) <0.001

Population: Patients with primary insomnia (sleep onset difficulty)

Review
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Dose: None vs.: None Outcome: ISWRD symptom management Wirkung: None None

Population: Patients with irregular sleep-wake rhythm disorder

review
Insomnia in older adults: A review of treatment options.
Dose: various vs.: Placebo Wirkung: None None
Review
Commonly encountered symptoms and their management in patients with cirrhosis.
Dose: None vs.: None Outcome: Pain outcomes Wirkung: None None

Population: Insomnia patients

Key Statistics

15

Studien

2000

Teilnehmer

Positive

C

Bewertung

Referenced Papers

Pediatrics in review 2026
Cleveland Clinic journal … 2025 12 Zitierungen
Current opinion in … 2024 12 Zitierungen
La Revue du … 2024
Progress in neuro-psychopharmacology … 2021 68 Zitierungen
Neurotherapeutics : the … 2020 80 Zitierungen
Current treatment options … 2020 29 Zitierungen
Human brain mapping 2020 15 Zitierungen
Dermatitis : contact, … 2019 7 Zitierungen
Journal of sleep … 2017 1691 Zitierungen
Neurological research 2017 331 Zitierungen
Nutrients 2017 301 Zitierungen
Current treatment options … 2017 56 Zitierungen
Clinical therapeutics 2016 328 Zitierungen
Chest 2016 109 Zitierungen
European heart journal. … 2016 77 Zitierungen
Diabetes, obesity & … 2015 132 Zitierungen
Alcohol (Fayetteville, N.Y.) 2015 122 Zitierungen
Pharmacological reports : … 2011 99 Zitierungen
Tidsskrift for den … 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
0.5-5 mg/day
sleepcognitivesupport:
0.5-3 mg 30-60 min before bed

Obergrenze: 10 mg/day (higher doses not more effective)

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) -- Positive --
None -- Positive --
20 mg or 50 mg tasimelteon daily 5 weeks Positive 322
None -- Mixed --
various -- Positive --
None -- Neutral --
None -- Positive 6528
Z-drugs, melatonin, orexin antagonists -- Positive --

Beste Einnahmezeit: 30-60 minutes before bedtime

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Daytime drowsiness
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams

Bekannte Wechselwirkungen

  • Sedative medications (additive drowsiness)
  • Blood thinners (may increase bleeding risk)
  • Diabetes medications (may affect blood sugar)
  • Immunosuppressants (may stimulate immune function)
  • Oral contraceptives (may increase melatonin levels)

Tolerierbare Höchstaufnahmemenge: 10 mg/day (higher doses not more effective)

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Melatonin help with Sleep-Related Cognitive Impairment?
Based on 15 studies with 2,000 participants, there is limited but promising evidence that Melatonin may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Melatonin should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 0.5-5 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Andere Inhaltsstoffe für Sleep-Related Cognitive Impairment

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