Melatonin untuk Sleep-Related Cognitive Impairment
C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
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C
Kesimpulan
Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
Key Study Findings
review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)
vs: Placebo
Efek: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence
None
Other
Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin …
Dose: None
vs: PCPA-induced insomnia model control
Outcome: Sleep quality and cognitive function in rat model
Efek: None
None
Populasi: PCPA-induced insomnia male rats
Randomized Controlled Trial
n=322
5 weeks
Double-blind
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, …
Dose: 20 mg or 50 mg tasimelteon daily
vs: Placebo
Outcome: Latency to persistent sleep (PSG)
Efek: -44.9 min (20mg) / -46.3 min (50mg) vs -28.2 (placebo)
<0.001
Populasi: Patients with primary insomnia (sleep onset difficulty)
Review
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Dose: None
vs: None
Outcome: ISWRD symptom management
Efek: None
None
Populasi: Patients with irregular sleep-wake rhythm disorder
review
Insomnia in older adults: A review of treatment options.
Dose: various
vs: Placebo
Efek: None
None
Review
Commonly encountered symptoms and their management in patients with cirrhosis.
Dose: None
vs: None
Outcome: Pain outcomes
Efek: None
None
Populasi: Insomnia patients
Key Statistics
15
Studi
2000
Peserta
↑
Positive
C
Peringkat
Referenced Papers
Pediatric Insomnia.
Review
Pediatrics in review
2026
Cleveland Clinic journal …
2025
12 sitasi
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Review
Handbook of clinical …
2025
4 sitasi
PloS one
2025
1 sitasi
Neurochemical research
2025
Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis.
Meta-Analysis
JNCI cancer spectrum
2024
24 sitasi
Journal of neurology
2024
21 sitasi
Antioxidants (Basel, Switzerland)
2024
17 sitasi
Current opinion in …
2024
12 sitasi
Frontiers in medicine
2024
4 sitasi
La Revue du …
2024
Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
Systematic Review
Journal of sleep …
2023
12 sitasi
Journal of pineal …
2023
7 sitasi
Frontiers in neuroscience
2023
5 sitasi
Current drug safety
2023
2 sitasi
BMJ open
2022
3 sitasi
NPJ Parkinson's disease
2022
Progress in neuro-psychopharmacology …
2021
68 sitasi
Frontiers in neurology
2021
16 sitasi
A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary …
Systematic Review
The Senior care …
2021
12 sitasi
Neural regeneration research
2021
6 sitasi
Climacteric : the …
2020
97 sitasi
Neurotherapeutics : the …
2020
80 sitasi
Current treatment options …
2020
29 sitasi
Human brain mapping
2020
15 sitasi
Dermatitis : contact, …
2019
7 sitasi
Journal of sleep …
2017
1691 sitasi
Neurological research
2017
331 sitasi
Nutrients
2017
301 sitasi
Current treatment options …
2017
56 sitasi
Journal of pineal …
2017
45 sitasi
Clinical therapeutics
2016
328 sitasi
Pediatric Insomnia.
Review
Chest
2016
109 sitasi
European heart journal. …
2016
77 sitasi
Diabetes, obesity & …
2015
132 sitasi
Alcohol (Fayetteville, N.Y.)
2015
122 sitasi
Menopause (New York, …
2015
73 sitasi
Chest
2013
53 sitasi
PloS one
2012
14 sitasi
Pharmacological reports : …
2011
99 sitasi
Progress in neuro-psychopharmacology …
2011
71 sitasi
Der Nervenarzt
2009
6 sitasi
Pharmacotherapy
2007
117 sitasi
Tidsskrift for den …
2006
Brain research. Molecular …
2005
160 sitasi
Reviews of reproduction
1998
381 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 0.5-5 mg/day
- sleepcognitivesupport:
- 0.5-3 mg 30-60 min before bed
Batas atas: 10 mg/day (higher doses not more effective)
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) | -- | Positive | -- |
| None | -- | Positive | -- |
| 20 mg or 50 mg tasimelteon daily | 5 weeks | Positive | 322 |
| None | -- | Mixed | -- |
| various | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | 6528 |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
Waktu terbaik diminum: 30-60 minutes before bedtime
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams
Interaksi yang Diketahui
- ● Sedative medications (additive drowsiness)
- ● Blood thinners (may increase bleeding risk)
- ● Diabetes medications (may affect blood sugar)
- ● Immunosuppressants (may stimulate immune function)
- ● Oral contraceptives (may increase melatonin levels)
Asupan atas yang dapat ditoleransi: 10 mg/day (higher doses not more effective)
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Melatonin help with Sleep-Related Cognitive Impairment?
Based on 15 studies with 2,000 participants, there is limited but promising evidence that Melatonin may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Melatonin should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 0.5-5 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Sleep-Related Cognitive Impairment
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