Melatonin لـ Sleep-Related Cognitive Impairment
C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
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C
الخلاصة
Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
Key Study Findings
review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)
مقابل: Placebo
التأثير: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence
None
Other
Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin …
Dose: None
مقابل: PCPA-induced insomnia model control
Outcome: Sleep quality and cognitive function in rat model
التأثير: None
None
المجتمع المدروس: PCPA-induced insomnia male rats
Randomized Controlled Trial
n=322
5 weeks
Double-blind
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, …
Dose: 20 mg or 50 mg tasimelteon daily
مقابل: Placebo
Outcome: Latency to persistent sleep (PSG)
التأثير: -44.9 min (20mg) / -46.3 min (50mg) vs -28.2 (placebo)
<0.001
المجتمع المدروس: Patients with primary insomnia (sleep onset difficulty)
Review
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Dose: None
مقابل: None
Outcome: ISWRD symptom management
التأثير: None
None
المجتمع المدروس: Patients with irregular sleep-wake rhythm disorder
review
Insomnia in older adults: A review of treatment options.
Dose: various
مقابل: Placebo
التأثير: None
None
Review
Commonly encountered symptoms and their management in patients with cirrhosis.
Dose: None
مقابل: None
Outcome: Pain outcomes
التأثير: None
None
المجتمع المدروس: Insomnia patients
Key Statistics
15
الدراسات
2000
المشاركون
↑
Positive
C
التقييم
Referenced Papers
Pediatric Insomnia.
Review
Pediatrics in review
2026
Cleveland Clinic journal …
2025
12 اقتباسات
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Review
Handbook of clinical …
2025
4 اقتباسات
PloS one
2025
1 اقتباسات
Neurochemical research
2025
Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis.
Meta-Analysis
JNCI cancer spectrum
2024
24 اقتباسات
Journal of neurology
2024
21 اقتباسات
Antioxidants (Basel, Switzerland)
2024
17 اقتباسات
Current opinion in …
2024
12 اقتباسات
Frontiers in medicine
2024
4 اقتباسات
La Revue du …
2024
Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
Systematic Review
Journal of sleep …
2023
12 اقتباسات
Journal of pineal …
2023
7 اقتباسات
Frontiers in neuroscience
2023
5 اقتباسات
Current drug safety
2023
2 اقتباسات
BMJ open
2022
3 اقتباسات
NPJ Parkinson's disease
2022
Progress in neuro-psychopharmacology …
2021
68 اقتباسات
Frontiers in neurology
2021
16 اقتباسات
A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary …
Systematic Review
The Senior care …
2021
12 اقتباسات
Neural regeneration research
2021
6 اقتباسات
Climacteric : the …
2020
97 اقتباسات
Neurotherapeutics : the …
2020
80 اقتباسات
Current treatment options …
2020
29 اقتباسات
Human brain mapping
2020
15 اقتباسات
Dermatitis : contact, …
2019
7 اقتباسات
Journal of sleep …
2017
1691 اقتباسات
Neurological research
2017
331 اقتباسات
Nutrients
2017
301 اقتباسات
Current treatment options …
2017
56 اقتباسات
Journal of pineal …
2017
45 اقتباسات
Clinical therapeutics
2016
328 اقتباسات
Pediatric Insomnia.
Review
Chest
2016
109 اقتباسات
European heart journal. …
2016
77 اقتباسات
Diabetes, obesity & …
2015
132 اقتباسات
Alcohol (Fayetteville, N.Y.)
2015
122 اقتباسات
Menopause (New York, …
2015
73 اقتباسات
Chest
2013
53 اقتباسات
PloS one
2012
14 اقتباسات
Pharmacological reports : …
2011
99 اقتباسات
Progress in neuro-psychopharmacology …
2011
71 اقتباسات
Der Nervenarzt
2009
6 اقتباسات
Pharmacotherapy
2007
117 اقتباسات
Tidsskrift for den …
2006
Brain research. Molecular …
2005
160 اقتباسات
Reviews of reproduction
1998
381 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 0.5-5 mg/day
- sleepcognitivesupport:
- 0.5-3 mg 30-60 min before bed
الحد الأعلى: 10 mg/day (higher doses not more effective)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) | -- | Positive | -- |
| None | -- | Positive | -- |
| 20 mg or 50 mg tasimelteon daily | 5 weeks | Positive | 322 |
| None | -- | Mixed | -- |
| various | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | 6528 |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
أفضل وقت للتناول: 30-60 minutes before bedtime
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams
التفاعلات المعروفة
- ● Sedative medications (additive drowsiness)
- ● Blood thinners (may increase bleeding risk)
- ● Diabetes medications (may affect blood sugar)
- ● Immunosuppressants (may stimulate immune function)
- ● Oral contraceptives (may increase melatonin levels)
الحد الأقصى المسموح به: 10 mg/day (higher doses not more effective)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Melatonin help with Sleep-Related Cognitive Impairment?
Based on 15 studies with 2,000 participants, there is limited but promising evidence that Melatonin may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Melatonin should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 0.5-5 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Sleep-Related Cognitive Impairment
References
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