Ashwagandha لـ Sleep-Related Cognitive Impairment
C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.
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C
الخلاصة
Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.
Key Study Findings
Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: narrative review of ashwagandha clinical trials and basic research (1994-present)
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
مقابل: Placebo
التأثير: None
None
animal_study
Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …
Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)
مقابل: Placebo
التأثير: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001);
<0.0001
In Vitro
Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …
Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)
مقابل: Placebo
التأثير: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker
Key Statistics
6
الدراسات
500
المشاركون
↑
Positive
C
التقييم
Referenced Papers
Nutrients
2026
Journal of ethnopharmacology
2025
9 اقتباسات
Preventive nutrition and …
2022
18 اقتباسات
Journal of ethnopharmacology
2021
69 اقتباسات
Journal of ethnopharmacology
2020
85 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 300-600 mg/day of root extract (KSM-66 or Sensoril)
- cognitivesupport:
- 600 mg/day
الحد الأعلى: Not established; well-tolerated up to 1,250 mg/day
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) | -- | Positive | -- |
| ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model) | -- | Positive | -- |
أفضل وقت للتناول: With meals; morning or evening depending on individual response
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Drowsiness
- ⚠ Gastrointestinal discomfort
- ⚠ Rare: liver injury (with contaminated or high-dose products)
- ⚠ Thyroid hormone elevation (may affect thyroid medications)
التفاعلات المعروفة
- ● Thyroid medications (may increase thyroid hormone levels)
- ● Sedative medications (additive CNS depression)
- ● Immunosuppressants (may stimulate immune activity)
- ● Diabetes medications (may lower blood sugar)
الحد الأقصى المسموح به: Not established; well-tolerated up to 1,250 mg/day
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Ashwagandha help with Sleep-Related Cognitive Impairment?
Based on 6 studies with 500 participants, there is limited but promising evidence that Ashwagandha may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Ashwagandha should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ashwagandha?
Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ashwagandha and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Sleep-Related Cognitive Impairment
Ashwagandha لحالات أخرى
References
- [1] Kaj Winther. Nutrients. 2026. The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. doi:10.3390/nu18050871 PubMed
- [2] Hyeongyeong Kim et al.. J Ethnopharmacol. 2025. Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … doi:10.1016/j.jep.2024.119224 PubMed
- [3] Sindgi Vasudeva Murthy et al.. Prev Nutr Food Sci. 2022. Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … doi:10.3746/pnf.2022.27.1.108 PubMed
- [4] Heba M A Khalil et al.. J Ethnopharmacol. 2021. Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … doi:10.1016/j.jep.2021.114141 PubMed
- [5] Nawab John Dar et al.. J Ethnopharmacol. 2020. Neurodegenerative diseases and Withania somnifera (L.): An update. doi:10.1016/j.jep.2020.112769 PubMed
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