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Ashwagandha per Sleep-Related Cognitive Impairment

C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.

Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.

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In sintesi

            
            
Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Effetto: None
                
                
                None
                
            

            
            
Popolazione: narrative review of ashwagandha clinical trials and basic research (1994-present)

            
        

        
        

            

                
                    preclinical animal/in vitro study
                
                
                
                
            

            
                Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
            
            

                
                Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
                
                
                vs: Placebo
                
                
                
                Effetto: None
                
                
                None
                
            

            
        

        
        

            

                
                    animal_study
                
                
                
                
            

            
                Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …
            
            

                
                Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)
                
                
                vs: Placebo
                
                
                
                Effetto: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001);
                
                
                <0.0001
                
            

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …
            
            

                
                Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)
                
                
                vs: Placebo
                
                
                
                Effetto: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker
                
                
            

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Studi

    

    

        
500

        
Partecipanti

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grado

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2026
                        
                    

                

                
                

                    

                        
                            Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2025
                        
                        9 citazioni
                        
                    

                

                
                

                    

                        
                            Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Preventive nutrition and …
                        2022
                        
                        18 citazioni
                        
                    

                

                
                

                    

                        
                            Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2021
                        
                        69 citazioni
                        
                    

                

                
                

                    

                        
                            Neurodegenerative diseases and Withania somnifera (L.): An update.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2020
                        
                        85 citazioni
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosaggi di uso comune

                

                    
                    

                        
general:

                        
300-600 mg/day of root extract (KSM-66 or Sensoril)

                    

                    
                    

                        
cognitivesupport:

                        
600 mg/day

                    

                    
                

                
                

                    Limite massimo: Not established; well-tolerated up to 1,250 mg/day
                

                
            

            

            
            

                
Dosaggi studiati nella ricerca

                

                    

                        
                            

                                Dosaggio
                                Durata
                                Effetto
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Momento migliore per l'assunzione: With meals; morning or evening depending on individual response
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effetti collaterali segnalati

                    
    
                        
                        
  • 
                            ⚠
                            Drowsiness
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare: liver injury (with contaminated or high-dose products)
                        
    • 
                        
                        
  • 
                            ⚠
                            Thyroid hormone elevation (may affect thyroid medications)
                        
    • 
                        
                    

                

                

                
                

                    
Interazioni note

                    
    
                        
                        
  • 
                            ●
                            Thyroid medications (may increase thyroid hormone levels)
                        
    • 
                        
                        
  • 
                            ●
                            Sedative medications (additive CNS depression)
                        
    • 
                        
                        
  • 
                            ●
                            Immunosuppressants (may stimulate immune activity)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may lower blood sugar)
                        
    • 
                        
                    

                

                

                
                

                    

                        Livello di assunzione massimo tollerabile: Not established; well-tolerated up to 1,250 mg/day
                    

                

                
            

            

                Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Ashwagandha help with Sleep-Related Cognitive Impairment?
            
        
        

            Based on 6 studies with 500 participants, there is limited but promising evidence that Ashwagandha may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Ashwagandha should I take for Sleep-Related Cognitive Impairment?
            
        
        

            Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Ashwagandha?
            
        
        

            Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Ashwagandha and Sleep-Related Cognitive Impairment?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Altri ingredienti per Sleep-Related Cognitive Impairment

                    

                        
                        
                            Melatonin
                            C

                        
                        
                        
                            L-Theanine
                            C

                        
                        
                        
                            Magnesium L-Threonate
                            C

                        
                        
                        
                            Creatine
                            C

                        
                        
                    

                

                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Kaj Winther.
      Nutrients.
      2026.
      The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review.
      doi:10.3390/nu18050871
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Hyeongyeong Kim et al..
      J Ethnopharmacol.
      2025.
      Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic …
      doi:10.1016/j.jep.2024.119224
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Sindgi Vasudeva Murthy et al..
      Prev Nutr Food Sci.
      2022.
      Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo …
      doi:10.3746/pnf.2022.27.1.108
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Heba M A Khalil et al..
      J Ethnopharmacol.
      2021.
      Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of …
      doi:10.1016/j.jep.2021.114141
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Nawab John Dar et al..
      J Ethnopharmacol.
      2020.
      Neurodegenerative diseases and Withania somnifera (L.): An update.
      doi:10.1016/j.jep.2020.112769
      PubMed
    
    6. 
    
  















    

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        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.