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Ashwagandha untuk Sleep-Related Cognitive Impairment

C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.

Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.

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Kesimpulan

            
            
Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: narrative review of ashwagandha clinical trials and basic research (1994-present)

            
        

        
        

            

                
                    preclinical animal/in vitro study
                
                
                
                
            

            
                Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
            
            

                
                Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
                
                
                vs: Placebo
                
                
                
                Efek: None
                
                
                None
                
            

            
        

        
        

            

                
                    animal_study
                
                
                
                
            

            
                Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …
            
            

                
                Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)
                
                
                vs: Placebo
                
                
                
                Efek: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001);
                
                
                <0.0001
                
            

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …
            
            

                
                Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)
                
                
                vs: Placebo
                
                
                
                Efek: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker
                
                
            

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Studi

    

    

        
500

        
Peserta

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Peringkat

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2026
                        
                    

                

                
                

                    

                        
                            Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2025
                        
                        9 sitasi
                        
                    

                

                
                

                    

                        
                            Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Preventive nutrition and …
                        2022
                        
                        18 sitasi
                        
                    

                

                
                

                    

                        
                            Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2021
                        
                        69 sitasi
                        
                    

                

                
                

                    

                        
                            Neurodegenerative diseases and Withania somnifera (L.): An update.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2020
                        
                        85 sitasi
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosis yang Umum Digunakan

                

                    
                    

                        
general:

                        
300-600 mg/day of root extract (KSM-66 or Sensoril)

                    

                    
                    

                        
cognitivesupport:

                        
600 mg/day

                    

                    
                

                
                

                    Batas atas: Not established; well-tolerated up to 1,250 mg/day
                

                
            

            

            
            

                
Dosis yang Diteliti dalam Penelitian

                

                    

                        
                            

                                Dosis
                                Durasi
                                Efek
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Waktu terbaik diminum: With meals; morning or evening depending on individual response
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efek Samping yang Dilaporkan

                    
    
                        
                        
  • 
                            ⚠
                            Drowsiness
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare: liver injury (with contaminated or high-dose products)
                        
    • 
                        
                        
  • 
                            ⚠
                            Thyroid hormone elevation (may affect thyroid medications)
                        
    • 
                        
                    

                

                

                
                

                    
Interaksi yang Diketahui

                    
    
                        
                        
  • 
                            ●
                            Thyroid medications (may increase thyroid hormone levels)
                        
    • 
                        
                        
  • 
                            ●
                            Sedative medications (additive CNS depression)
                        
    • 
                        
                        
  • 
                            ●
                            Immunosuppressants (may stimulate immune activity)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may lower blood sugar)
                        
    • 
                        
                    

                

                

                
                

                    

                        Asupan atas yang dapat ditoleransi: Not established; well-tolerated up to 1,250 mg/day
                    

                

                
            

            

                Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Ashwagandha help with Sleep-Related Cognitive Impairment?
            
        
        

            Based on 6 studies with 500 participants, there is limited but promising evidence that Ashwagandha may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Ashwagandha should I take for Sleep-Related Cognitive Impairment?
            
        
        

            Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Ashwagandha?
            
        
        

            Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Ashwagandha and Sleep-Related Cognitive Impairment?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Bahan lain untuk Sleep-Related Cognitive Impairment

                    

                        
                        
                            Melatonin
                            C

                        
                        
                        
                            L-Theanine
                            C

                        
                        
                        
                            Magnesium L-Threonate
                            C

                        
                        
                        
                            Creatine
                            C

                        
                        
                    

                

                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Kaj Winther.
      Nutrients.
      2026.
      The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review.
      doi:10.3390/nu18050871
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Hyeongyeong Kim et al..
      J Ethnopharmacol.
      2025.
      Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic …
      doi:10.1016/j.jep.2024.119224
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Sindgi Vasudeva Murthy et al..
      Prev Nutr Food Sci.
      2022.
      Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo …
      doi:10.3746/pnf.2022.27.1.108
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Heba M A Khalil et al..
      J Ethnopharmacol.
      2021.
      Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of …
      doi:10.1016/j.jep.2021.114141
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Nawab John Dar et al..
      J Ethnopharmacol.
      2020.
      Neurodegenerative diseases and Withania somnifera (L.): An update.
      doi:10.1016/j.jep.2020.112769
      PubMed
    
    6. 
    
  















    

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