What is the recommended dosage for Vitamin B6?

General: 1.3-2.0 mg/day (RDA); Cognitive Support: 25-100 mg/day

What are the side effects of Vitamin B6?

Potential side effects include: Peripheral neuropathy at chronic high doses (>200 mg/day), Photosensitivity, Nausea.

Vitamin B6 (pyridoxine) is an essential vitamin involved in over 100 enzymatic reactions, including the synthesis of neurotransmitters such as serotonin, dopamine, and GABA. Adequate B6 status supports cognitive function and is important for homocysteine metabolism alongside folate and B12.

What dosage of Vitamin B6 has been used in cognitive studies?

Cognitive studies have used 2 mg to 50 mg of vitamin B6 daily, often combined with folate and B12 to target homocysteine levels. The RDA is 1.3 to 1.7 mg for adults. Pyridoxal-5-phosphate (P5P) is the active coenzyme form. The tolerable upper intake is 100 mg per day. Consult your doctor.

What are the potential side effects of Vitamin B6?

Vitamin B6 is generally safe at recommended doses. However, chronic intake above 200 mg per day has been associated with peripheral neuropathy (nerve damage causing numbness and tingling). This is typically reversible upon discontinuation. Consult your healthcare provider for appropriate dosing.

Vitamin B6

vitamin

Also known as: Pyridoxine, Pyridoxal 5'-Phosphate, P5P, Pyridoxamine

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About

Vitamin B6 is essential for neurotransmitter synthesis including serotonin, dopamine, GABA, and norepinephrine, participating in over 100 enzymatic reactions. It supports homocysteine metabolism alongside B12 and folate.

How It Works

Essential cofactor for neurotransmitter synthesis (serotonin, dopamine, GABA, norepinephrine); participates in over 100 enzymatic reactions; supports homocysteine metabolism alongside B12 and folate.

Side Effects

Peripheral neuropathy at chronic high doses (>200 mg/day)
Photosensitivity
Nausea

Drug & Supplement Interactions

Levodopa (reduces efficacy without carbidopa)
Phenytoin (mutual metabolism effects)
Cycloserine (increases B6 excretion)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Folate Niacin Vitamin B12 Vitamin D Vitamin E

Quick Facts

Dosage: General: 1.3-2.0 mg/day (RDA); Cognitive_Support: 25-100 mg/day
Forms: capsule tablet
Natural Sources: Poultry, Fish, Potatoes, Chickpeas, Bananas, Fortified cereals
Upper Limit: 100 mg/day (peripheral neuropathy risk at high doses)
Best Time: With meals

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.