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Magnesium L-Threonate per Sleep-Related Cognitive Impairment

C

Research suggests magnesium L-threonate may support sleep quality and sleep-dependent memory consolidation through NMDA receptor modulation in brain regions involved in sleep regulation.

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            C

        

        

            
In sintesi

            
            
Research suggests magnesium L-threonate may support sleep quality and sleep-dependent memory consolidation through NMDA receptor modulation in brain regions involved in sleep regulation.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Age-related memory decline via NR2B upregulation
                
                
                Effetto: None
                
                
                None
                
            

            
            
Popolazione: Elderly with age-related memory decline

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
4

        
Studi

    

    

        
300

        
Partecipanti

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grado

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Expert opinion on …
                        2014
                        
                        55 citazioni
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosaggi di uso comune

                

                    
                    

                        
general:

                        
1,500-2,000 mg/day (providing ~144 mg elemental magnesium)

                    

                    
                    

                        
cognitivesupport:

                        
2,000 mg/day

                    

                    
                

                
                

                    Limite massimo: 350 mg/day elemental magnesium from supplements (IOM)
                

                
            

            

            
            

                
Dosaggi studiati nella ricerca

                

                    

                        
                            

                                Dosaggio
                                Durata
                                Effetto
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Momento migliore per l'assunzione: Evening preferred (may support sleep quality); split into 2-3 doses
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effetti collaterali segnalati

                    
    
                        
                        
  • 
                            ⚠
                            Drowsiness
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild diarrhea
                        
    • 
                        
                    

                

                

                
                

                    
Interazioni note

                    
    
                        
                        
  • 
                            ●
                            Antibiotics (quinolones, tetracyclines — reduced absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Bisphosphonates (reduced absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Diuretics (may affect magnesium levels)
                        
    • 
                        
                        
  • 
                            ●
                            Muscle relaxants (additive sedation)
                        
    • 
                        
                    

                

                

                
                

                    

                        Livello di assunzione massimo tollerabile: 350 mg/day elemental magnesium from supplements (IOM)
                    

                

                
            

            

                Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Magnesium L-Threonate help with Sleep-Related Cognitive Impairment?
            
        
        

            Based on 4 studies with 300 participants, there is limited but promising evidence that Magnesium L-Threonate may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Magnesium L-Threonate should I take for Sleep-Related Cognitive Impairment?
            
        
        

            Studies have used various dosages. A commonly studied range is 1,500-2,000 mg/day (providing ~144 mg elemental magnesium). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Magnesium L-Threonate?
            
        
        

            Reported side effects may include Drowsiness, Headache, Gastrointestinal discomfort, Mild diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Magnesium L-Threonate and Sleep-Related Cognitive Impairment?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Altri ingredienti per Sleep-Related Cognitive Impairment

                    

                        
                        
                            Melatonin
                            C

                        
                        
                        
                            Ashwagandha
                            C

                        
                        
                        
                            L-Theanine
                            C

                        
                        
                        
                            Creatine
                            C

                        
                        
                    

                

                

                
                

                    
Magnesium L-Threonate per altre condizioni

                    

                        
                        
                            Memory Loss
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

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        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.