Phosphatidylserine ： Attention & Focus Difficulties

Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.

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結論

Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.

Key Study Findings

Other

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …

Dose: 50 mg/kg lycopene in mice vs: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) 効果: None None

対象集団: HFD-induced obese male C57BL/6 mice

In Vitro

The uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) may enhance eryptosis and increase erythrocyte osmotic fragility through potential …

Dose: None vs: None Outcome: CMPF-induced eryptosis via PIEZO1 activation 効果: None None

対象集団: Human red blood cells from healthy individuals

Other

Initiation of Progressive Morphological Transition Towards an Echino-Stomato-Spherocytic Phenotype by Phosphatidylserine Externalization and Its Implication …

Dose: None vs: Untreated erythrocytes Outcome: Erythrocyte morphological transition and thrombosis 効果: None None

対象集団: Rat erythrocytes (in vitro/in vivo)

Other

Milk Fat Globules: 2024 Updates.

Dose: None vs: None Outcome: Inflammatory markers 効果: None None

対象集団: None

Randomized Controlled Trial n=138 6.0 weeks Double-blind

A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract …

Dose: None vs: placebo Outcome: cognitive function 効果: None p ≤ 0.024

対象集団: Adults with cognitive concerns

In Vitro

Concentration of Phosphatidylserine Influence Rates of Insulin Aggregation and Toxicity of Amyloid Aggregates In Vitro.

Dose: 40% vs: None Outcome: lipid levels 効果: None None

対象集団: None

Key Statistics

研究数

350

参加者数

↑

Positive

グレード

Referenced Papers

The uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) may enhance eryptosis and increase erythrocyte osmotic fragility through potential activation of PIEZO1. Other

Nephrology, dialysis, transplantation … 2025 3 件の引用

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. Other

Clinical nutrition (Edinburgh, … 2025 1 件の引用

Initiation of Progressive Morphological Transition Towards an Echino-Stomato-Spherocytic Phenotype by Phosphatidylserine Externalization and Its Implication in Thrombosis. Other

International journal of … 2025 1 件の引用

Milk Fat Globules: 2024 Updates. Other

Newborn (Clarksville, Md.) 2024 9 件の引用

A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive … Other

Neurology and therapy 2023 9 件の引用

Concentration of Phosphatidylserine Influence Rates of Insulin Aggregation and Toxicity of Amyloid Aggregates In Vitro. Other

ACS chemical neuroscience 2023 7 件の引用

Polo-like kinase inhibitor BI2536 induces eryptosis. Other

Wiener medizinische Wochenschrift … 2023 4 件の引用

Iodixanol supplementation in freezing extender improves the antioxidant capacity of semen. Other

Reproduction in domestic … 2023 1 件の引用

TMEM16F mediated phosphatidylserine exposure and microparticle release on erythrocyte contribute to hypercoagulable state in hyperuricemia. Other

Blood cells, molecules … 2022 12 件の引用

[Mechanism of Leakage in Phosphatidylserine-Containing Membranes by Melittin]. Other

Molekuliarnaia biologiia 2022

Effects of storage and leukocyte reduction on the concentration and procoagulant activity of extracellular vesicles in canine packed red cells. Other

Journal of veterinary … 2021 7 件の引用

Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. Other

Frontiers in medicine 2021 6 件の引用

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 件の引用

Intracellular Ca2+ Concentration and Phosphatidylserine Exposure in Healthy Human Erythrocytes in Dependence on in vivo Cell Age. Review

Frontiers in physiology 2019 20 件の引用

Extracellular vesicle concentration and procoagulant activity of canine haemoperitoneum fluid and packed red blood cells. Other

The Journal of … 2019 2 件の引用

Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. Other

Frontiers in psychology 2018 13 件の引用

Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches. Other

Oncotarget 2017 35 件の引用

Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine. Other

Cellular physiology and … 2017 17 件の引用

Stereochemistry- and concentration-dependent effects of phosphatidylserine enrichment on platelet function. Other

Biochimica et biophysica … 2017 1 件の引用

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … RCT

Nutrients 2016 53 件の引用

Storage of Erythrocytes Induces Suicidal Erythrocyte Death. Other

Cellular physiology and … 2016 50 件の引用

Isolation and Analysis of Phospholipids in Dairy Foods. Review

Journal of analytical … 2016 49 件の引用

Role of tissue factor expression in thrombin generation by canine tumor cells. Other

American journal of … 2016 7 件の引用

Phosphatidylserine and the human brain. Review

Nutrition (Burbank, Los … 2015 149 件の引用

Enhanced suicidal erythrocyte death in acute cardiac failure. Other

European journal of … 2015 28 件の引用

Enhanced eryptosis following juglone exposure. Other

Basic & clinical … 2015 17 件の引用

[Molecular regulations of phosphatidylserine eversion in plasma membrane]. Review

Yi chuan = … 2015 4 件の引用

Quantitative analysis of annexin V-membrane interaction by flow cytometry. Other

European biophysics journal … 2015

Suicidal erythrocyte death in end-stage renal disease. Other

Journal of molecular … 2014 138 件の引用

Geldanamycin-induced phosphatidylserine translocation in the erythrocyte membrane. Other

Cellular physiology and … 2013 53 件の引用

Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity. Other

PloS one 2013 12 件の引用

Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease. Other

Journal of Alzheimer's … 2012 257 件の引用

Phosphatidylserine dynamics in cellular membranes. Other

Molecular biology of … 2012 173 件の引用

Apigenin-induced suicidal erythrocyte death. Other

Journal of agricultural … 2012 33 件の引用

Hexavalent chromium-induced erythrocyte membrane phospholipid asymmetry. Other

Biometals : an … 2012

Stimulation of suicidal erythrocyte death by oridonin. Other

Archives of biochemistry … 2011 20 件の引用

Inhibition of suicidal erythrocyte death by blebbistatin. Other

American journal of … 2011 17 件の引用

Formation of procoagulant microparticles and properties. Review

Thrombosis research 2010 155 件の引用

Monensin induced suicidal erythrocyte death. Other

Cellular physiology and … 2010 51 件の引用

Differences in CSF phospholipid concentration by traumatic brain injury outcome. Other

Biological research for … 2010 49 件の引用

Lactadherin and clearance of platelet-derived microvesicles. Other

Blood 2009 204 件の引用

Arsenic-induced suicidal erythrocyte death. Other

Archives of toxicology 2009 78 件の引用

Vanadate-induced suicidal erythrocyte death. Other

Kidney & blood … 2008 62 件の引用

Suicidal death of erythrocytes due to selenium-compounds. Other

Cellular physiology and … 2008 46 件の引用

In vitro and in vivo characterization of a combination chemotherapy formulation consisting of vinorelbine and phosphatidylserine. Other

European journal of … 2007 34 件の引用

Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Review

Alternative medicine review … 2007

Enhanced programmed cell death of iron-deficient erythrocytes. Other

FASEB journal : … 2006 244 件の引用

Induction of eryptosis by cyclosporine. Other

Naunyn-Schmiedeberg's archives of … 2006 63 件の引用

Surface exposure of phosphatidylserine in pathological cells. Review

Cellular and molecular … 2005 747 件の引用

Erythrocyte ion channels in regulation of apoptosis. Review

Advances in experimental … 2004 29 件の引用

Metabolism and functions of phosphatidylserine in mammalian brain. Review

Neurochemical research 2003 82 件の引用

The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. CCT

Nutritional neuroscience 2001 66 件の引用

Oxidation and erythrocyte senescence. Review

Current opinion in … 2000 256 件の引用

A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Review

Alternative medicine review … 1999 112 件の引用

N-stearoyl-phosphatidylserine: synthesis and role in divalent-cation-induced aggregation and fusion. Other

Lipids 1998 6 件の引用

Interaction of bovine heart pyruvate kinase with phospholipids. Other

Biochimica et biophysica … 1995 7 件の引用

Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site? Other

Cell 1983 307 件の引用

Binding of monovalent cations to phosphatidylserine and modulation of Ca2+- and Mg2+-induced vesicle fusion. Other

Biochimica et biophysica … 1983 55 件の引用

Spectrin-phospholipid interaction. A monolayer study. Other

Biochimica et biophysica … 1980 118 件の引用

Fusion of phosphatidylserine and mixed phosphatidylserine-phosphatidylcholine vesicles. Dependence on calcium concentration and temperature. Other

Biochimica et biophysica … 1979 28 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 100 mg/day
cognitivesupport:: 100-300 mg/day

上限量： Well-tolerated up to 600 mg/day

研究で検討された用量

用量	期間	効果	N
50 mg/kg lycopene in mice	--	Positive	--
None	--	Negative	--
None	--	Negative	--
None	--	Positive	--
None	6.0 weeks	Mixed	138
40%	--	Mixed	--
None	--	Mixed	--
4 g	--	Mixed	--

推奨摂取タイミング： With meals for better absorption

Safety & Side Effects

報告されている副作用

⚠ Mild gastrointestinal discomfort
⚠ Insomnia at high doses
⚠ Rare allergic reactions (soy-derived forms)

既知の相互作用

● Anticholinergic medications (may reduce PS effectiveness)
● Blood thinners (theoretical interaction)
● Cholinesterase inhibitors (additive cholinergic effects)

耐容上限摂取量： Well-tolerated up to 600 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Phosphatidylserine help with Attention & Focus Difficulties?

Based on 5 studies with 350 participants, there is limited but promising evidence that Phosphatidylserine may support Attention & Focus Difficulties management. Our evidence grade is C (Some Evidence).

How much Phosphatidylserine should I take for Attention & Focus Difficulties?

Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Phosphatidylserine?

Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Phosphatidylserine and Attention & Focus Difficulties?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Attention & Focus Difficulties

L-Theanine B Citicoline B Omega-3 Fatty Acids (DHA/EPA) C Bacopa monnieri C

Phosphatidylserine 他の症状・状態について

Age-Related Cognitive Decline B Stress-Induced Cognitive Decline C

総合評価

Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (1)Meta (0)Other (4)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Attention & Focus Difficulties

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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。