Melatonin 관련 Sleep-Related Cognitive Impairment
CWell-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
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C
결론
Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
Key Study Findings
review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)
vs: Placebo
효과: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence
None
Other
Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin …
Dose: None
vs: PCPA-induced insomnia model control
Outcome: Sleep quality and cognitive function in rat model
효과: None
None
대상 집단: PCPA-induced insomnia male rats
Randomized Controlled Trial
n=322
5 weeks
Double-blind
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, …
Dose: 20 mg or 50 mg tasimelteon daily
vs: Placebo
Outcome: Latency to persistent sleep (PSG)
효과: -44.9 min (20mg) / -46.3 min (50mg) vs -28.2 (placebo)
<0.001
대상 집단: Patients with primary insomnia (sleep onset difficulty)
Review
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Dose: None
vs: None
Outcome: ISWRD symptom management
효과: None
None
대상 집단: Patients with irregular sleep-wake rhythm disorder
review
Insomnia in older adults: A review of treatment options.
Dose: various
vs: Placebo
효과: None
None
Review
Commonly encountered symptoms and their management in patients with cirrhosis.
Dose: None
vs: None
Outcome: Pain outcomes
효과: None
None
대상 집단: Insomnia patients
Key Statistics
15
연구
2000
참여자
↑
Positive
C
등급
Referenced Papers
Pediatric Insomnia.
Review
Pediatrics in review
2026
Cleveland Clinic journal …
2025
12 인용
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Review
Handbook of clinical …
2025
4 인용
PloS one
2025
1 인용
Neurochemical research
2025
Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis.
Meta-Analysis
JNCI cancer spectrum
2024
24 인용
Journal of neurology
2024
21 인용
Antioxidants (Basel, Switzerland)
2024
17 인용
Current opinion in …
2024
12 인용
Frontiers in medicine
2024
4 인용
La Revue du …
2024
Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
Systematic Review
Journal of sleep …
2023
12 인용
Journal of pineal …
2023
7 인용
Frontiers in neuroscience
2023
5 인용
Current drug safety
2023
2 인용
BMJ open
2022
3 인용
NPJ Parkinson's disease
2022
Progress in neuro-psychopharmacology …
2021
68 인용
Frontiers in neurology
2021
16 인용
A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary …
Systematic Review
The Senior care …
2021
12 인용
Neural regeneration research
2021
6 인용
Climacteric : the …
2020
97 인용
Neurotherapeutics : the …
2020
80 인용
Current treatment options …
2020
29 인용
Human brain mapping
2020
15 인용
Dermatitis : contact, …
2019
7 인용
Journal of sleep …
2017
1691 인용
Neurological research
2017
331 인용
Nutrients
2017
301 인용
Current treatment options …
2017
56 인용
Journal of pineal …
2017
45 인용
Clinical therapeutics
2016
328 인용
Pediatric Insomnia.
Review
Chest
2016
109 인용
European heart journal. …
2016
77 인용
Diabetes, obesity & …
2015
132 인용
Alcohol (Fayetteville, N.Y.)
2015
122 인용
Menopause (New York, …
2015
73 인용
Chest
2013
53 인용
PloS one
2012
14 인용
Pharmacological reports : …
2011
99 인용
Progress in neuro-psychopharmacology …
2011
71 인용
Der Nervenarzt
2009
6 인용
Pharmacotherapy
2007
117 인용
Tidsskrift for den …
2006
Brain research. Molecular …
2005
160 인용
Reviews of reproduction
1998
381 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 0.5-5 mg/day
- sleepcognitivesupport:
- 0.5-3 mg 30-60 min before bed
상한량: 10 mg/day (higher doses not more effective)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) | -- | Positive | -- |
| None | -- | Positive | -- |
| 20 mg or 50 mg tasimelteon daily | 5 weeks | Positive | 322 |
| None | -- | Mixed | -- |
| various | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | 6528 |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
권장 복용 시간: 30-60 minutes before bedtime
Safety & Side Effects
보고된 부작용
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams
알려진 상호작용
- ● Sedative medications (additive drowsiness)
- ● Blood thinners (may increase bleeding risk)
- ● Diabetes medications (may affect blood sugar)
- ● Immunosuppressants (may stimulate immune function)
- ● Oral contraceptives (may increase melatonin levels)
일일 최대 섭취 허용량: 10 mg/day (higher doses not more effective)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Melatonin help with Sleep-Related Cognitive Impairment?
Based on 15 studies with 2,000 participants, there is limited but promising evidence that Melatonin may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Melatonin should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 0.5-5 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Sleep-Related Cognitive Impairment
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