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Overview of clinical trial design considerations for testing mitochondria-targeted interventions in neurodegenerative disease populations, including patient selection criteria and biomarker endpoints.

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![Figure 26: Overview of clinical trial design considerations for testing mitochondria-targeted interventions in neurodegenerative disease populations, including patient selection criteria and biomarker endpoints.]()

> Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." *Oxidative medicine and cellular longevity*, 2019. PMID: [31214285](https://pubmed.ncbi.nlm.nih.gov/31214285/)
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  <img src="" alt="Overview of clinical trial design considerations for testing mitochondria-targeted interventions in neurodegenerative disease populations, including patient selection criteria and biomarker endpoints." />
  <figcaption>Figure 26. Overview of clinical trial design considerations for testing mitochondria-targeted interventions in neurodegenerative disease populations, including patient selection criteria and biomarker endpoints.<br>  Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." <em>Oxidative medicine and cellular longevity</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31214285/">31214285</a></figcaption>
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