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Ginkgo biloba für Age-Related Cognitive Decline

C

The most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.

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C

Fazit

The most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.

Key Study Findings

Review
EGb761 Trials for Mild-to-Moderate Dementia-What Have We Learned in the Past 18 years?
Dose: None vs.: placebo Outcome: cognitive assessment scores (MMSE, SKT, NPI) Wirkung: None None

Population: patients with mild-to-moderate Alzheimer disease or vascular dementia

Review
Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.
Dose: None vs.: None Outcome: None Wirkung: None None

Population: patients with vascular cognitive impairment and dementia

Review
The Use of Natural Products for Preventing Cognitive Decline/Providing Neuroprotection.
Dose: None vs.: None Outcome: None Wirkung: None None

Population: Review of natural products for neuroprotection

Review
Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review.
Dose: None vs.: None Outcome: Cognitive function in multiple sclerosis Wirkung: None None

Population: Multiple sclerosis patients (review)

Review
Nutritional strategies against dementia in rural populations.
Dose: None vs.: None Outcome: None Wirkung: None None

Population: Rural populations with dementia risk

Cohort Study n=64 52 weeks Open-label
Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment.
Dose: 240 mg/day vs.: Standard cognitive enhancers Outcome: Cognitive responder rate and AD conversion Wirkung: 100% vs 59.1% responders; 0% vs 13.6% AD conversio <0.001 (responders); 0.037 (AD

Population: Amyloid PET-positive MCI patients

Key Statistics

40

Studien

8000

Teilnehmer

Mixed

C

Bewertung

Referenced Papers

Pharmaceuticals (Basel, Switzerland) 2021 33 Zitierungen
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 2020 4 Zitierungen
Acta bio-medica : … 2018 103 Zitierungen
Journal of Alzheimer's … 2017 17 Zitierungen
Age (Dordrecht, Netherlands) 2014
American family physician 2011
JAMA 2010 3 Zitierungen
The Practitioner 2010
The Cochrane database … 2009 299 Zitierungen
Neuro endocrinology letters 2008
The Cochrane database … 2007 375 Zitierungen
The Proceedings of … 2002 191 Zitierungen
The Cochrane database … 2002
Current opinion in … 1998 30 Zitierungen
British journal of … 1993 8 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones

Obergrenze: 600 mg/day (doses above show no additional benefit)

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Mixed --
None -- Mixed --
None -- Mixed --
None -- Mixed --
None -- Mixed --
240 mg/day 52 weeks Positive 64
None -- Positive --
None -- Neutral --

Beste Einnahmezeit: With meals; may require 4-6 weeks for full effects

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Headache
  • Gastrointestinal upset
  • Dizziness
  • Allergic skin reactions (rare)
  • Increased bleeding risk

Bekannte Wechselwirkungen

  • Anticoagulants and antiplatelet drugs (increased bleeding risk)
  • Anticonvulsants (may reduce seizure threshold)
  • SSRIs (serotonin syndrome risk, rare)
  • CYP3A4 substrates (may affect drug metabolism)

Tolerierbare Höchstaufnahmemenge: 600 mg/day (doses above show no additional benefit)

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Ginkgo biloba help with Age-Related Cognitive Decline?
Based on 40 studies with 8,000 participants, there is limited but promising evidence that Ginkgo biloba may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Ginkgo biloba should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ginkgo biloba?
Reported side effects may include Headache, Gastrointestinal upset, Dizziness, Allergic skin reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ginkgo biloba and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 40 peer-reviewed studies with 8,000 total participants. The overall direction of effect is mixed.

Related Evidence

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