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Gotu Kola pour Age-Related Cognitive Decline

D

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

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D

En conclusion

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

Key Study Findings

Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None vs: None Outcome: Cholinesterase inhibition and cognitive improvement Effet: None None

Population: In vivo animal models of AD

Controlled Clinical Trial
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day vs: Control chow Outcome: Sleep quality and quantity (EEG/EMG) Effet: None None

Population: 18-month-old male and female C57BL6/J mice

In Vitro
In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and …
Dose: None vs: H2O2-induced oxidative stress Outcome: Neuroprotection and cognitive decline biomarkers Effet: BDNF ~2.3-fold, NGF ~1.9-fold vs H2O2 None

Population: 3D intestinal model and neuronal/astrocytic co-culture

Other
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day vs: Control chow Outcome: Sleep composition (REM/NREM duration, arousals) Effet: None None

Population: Aged (18-month) C57BL6/J mice

Review
Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments.
Dose: None vs: None Outcome: DM and AD symptom management Effet: None None

Population: Patients with diabetes and Alzheimer's disease (review)

Other
Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants.
Dose: None vs: None Outcome: AChE and BACE1 inhibition for Alzheimer's Effet: None None

Population: In silico AD drug discovery (820 metabolites screened)

Key Statistics

4

Études

200

Participants

Positive

D

Note

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:
500-1,000 mg/day standardized extract
cognitivesupport:
750 mg/day

Limite supérieure : Not established; hepatotoxicity reported rarely at very high doses

Posologies étudiées dans la recherche

Posologie Durée Effet N
None -- Positive --
1000 mg/kg/day -- Positive --
None -- Positive --
1000 mg/kg/day -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
1 μg/mL -- Positive --

Moment optimal de prise : With meals

Safety & Side Effects

Effets indésirables signalés

  • Skin irritation (topical)
  • Headache
  • Gastrointestinal discomfort
  • Drowsiness
  • Rare: liver toxicity at very high doses

Interactions connues

  • Hepatotoxic drugs (additive liver stress)
  • Sedative medications (additive CNS depression)
  • Cholesterol-lowering drugs (theoretical interaction)

Apport maximal tolérable : Not established; hepatotoxicity reported rarely at very high doses

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Gotu Kola help with Age-Related Cognitive Decline?
Based on 4 studies with 200 participants, there is preliminary evidence that needs more research that Gotu Kola may support Age-Related Cognitive Decline management. Our evidence grade is D (Very Early Research).
How much Gotu Kola should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day standardized extract. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Gotu Kola?
Reported side effects may include Skin irritation (topical), Headache, Gastrointestinal discomfort, Drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Gotu Kola and Age-Related Cognitive Decline?
We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.