N-Acetyl Cysteine pour Post-Concussion Cognitive Symptoms

NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.

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En conclusion

NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.

Key Study Findings

Randomized Controlled Trial n=50 Open-label

Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With …

Dose: None vs: waitlist control (standard of care) Outcome: resting-state functional connectivity and cognitive-affective symptoms Effet: None p<0.05

Population: patients with chronic post-concussion syndrome for at least 3 months

Review

Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols.

Dose: None vs: None Outcome: TBI prevention and neuroprotection Effet: None None

Population: Individuals with or at risk for TBI

Controlled Clinical Trial n=65 4 weeks Open-label

N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study.

Dose: None vs: Standard care alone Outcome: RPQ postconcussion symptom severity Effet: RPQ day 7: 2 vs 10; day 30: 0 vs 4 p=0.004 (day 7); p=0.021 (day

Population: Elderly patients (>=60y) with mild TBI

Review

Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.

Dose: None vs: None Outcome: None Effet: None None

Population: restless legs syndrome

Review

Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?

Dose: None vs: None Outcome: None Effet: None None

Population: None

Review

Dietary Supplements for Health, Adaptation, and Recovery in Athletes.

Dose: None vs: None Outcome: Health, adaptation, and recovery in athletes Effet: None None

Population: Athletes

Key Statistics

Études

400

Participants

↑

Positive

Note

Referenced Papers

Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With N-Acetyl Cysteine. RCT

The Journal of … None

Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols. Review

Nutrients 2024 22 citations

N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study. Other

The journal of … 2022 7 citations

Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. Review

Sleep medicine clinics 2021 14 citations

Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? Review

Neuroscience and biobehavioral … 2019 45 citations

Dietary Supplements for Health, Adaptation, and Recovery in Athletes. Review

International journal of … 2018 165 citations

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 citations

Restless legs syndrome. Review

Handbook of clinical … 2011 8 citations

Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Other

Brain research. Molecular … 2005 160 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:: 600-1,800 mg/day
neuroprotection:: 1,200-2,400 mg/day

Limite supérieure : Not established as supplement; 6,000+ mg/day used clinically (IV)

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Positive	50
None	--	Positive	--
None	4 weeks	Positive	65
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
NAC 100 mg/kg body weight orally daily for 14 days	2 weeks	Positive	24
None	--	Mixed	--

Moment optimal de prise : On empty stomach; split into 2-3 doses; supplement zinc if using long-term

Safety & Side Effects

Effets indésirables signalés

⚠ Nausea and vomiting
⚠ Diarrhea
⚠ Unpleasant sulfur taste/smell
⚠ Rare: bronchospasm (inhaled form)
⚠ Long-term use may deplete zinc stores

Interactions connues

● Nitroglycerin (may enhance hypotensive effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical interaction)

Apport maximal tolérable : Not established as supplement; 6,000+ mg/day used clinically (IV)

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does N-Acetyl Cysteine help with Post-Concussion Cognitive Symptoms?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that N-Acetyl Cysteine may support Post-Concussion Cognitive Symptoms management. Our evidence grade is B (Good Evidence).

How much N-Acetyl Cysteine should I take for Post-Concussion Cognitive Symptoms?

Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetyl Cysteine?

Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetyl Cysteine and Post-Concussion Cognitive Symptoms?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

N-Acetyl Cysteine pour d'autres pathologies

Oxidative Stress & Neuroinflammation B Depression-Related Cognitive Dysfunction C

Verdict rapide

NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.

Evidence Strength72%

High confidence

Synthèse des études

RCT (1)Meta (0)Other (5)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Post-Concussion Cognitive Symptoms

En savoir plus

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