N-Acetyl Cysteine para Post-Concussion Cognitive Symptoms
B Evidências Pelo menos um ensaio aleatorizado apoia esta conclusão, com resultados maioritariamente consistentes.NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.
Conclusão
NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.
Key Study Findings
População: patients with chronic post-concussion syndrome for at least 3 months
População: Individuals with or at risk for TBI
População: Elderly patients (>=60y) with mild TBI
População: restless legs syndrome
População: None
População: Athletes
Key Statistics
6
Estudos
400
Participantes
Positive
Nota
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 600-1,800 mg/day
- neuroprotection:
- 1,200-2,400 mg/day
Limite superior: Not established as supplement; 6,000+ mg/day used clinically (IV)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Positive | 50 |
| None | -- | Positive | -- |
| None | 4 weeks | Positive | 65 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| NAC 100 mg/kg body weight orally daily for 14 days | 2 weeks | Positive | 24 |
| None | -- | Mixed | -- |
Melhor horário: On empty stomach; split into 2-3 doses; supplement zinc if using long-term
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Nausea and vomiting
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/smell
- ⚠ Rare: bronchospasm (inhaled form)
- ⚠ Long-term use may deplete zinc stores
Interações Conhecidas
- ● Nitroglycerin (may enhance hypotensive effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (theoretical interaction)
Ingestão máxima tolerável: Not established as supplement; 6,000+ mg/day used clinically (IV)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does N-Acetyl Cysteine help with Post-Concussion Cognitive Symptoms?
How much N-Acetyl Cysteine should I take for Post-Concussion Cognitive Symptoms?
Are there side effects of N-Acetyl Cysteine?
How strong is the evidence for N-Acetyl Cysteine and Post-Concussion Cognitive Symptoms?
Related Evidence
N-Acetyl Cysteine para outras condições
References
- [1] Daniel A Monti et al.. J Head Trauma Rehabil. Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With N-Acetyl Cysteine. doi:10.1097/HTR.0000000000000976 PubMed
- [2] Federica Conti et al.. Nutrients. 2024. Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols. doi:10.3390/nu16152430 PubMed
- [3] Ryan A Mcpherson et al.. J Trauma Acute Care Surg. 2022. N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study. doi:10.1097/TA.0000000000003639 PubMed
- [4] Sergi Ferré et al.. Sleep Med Clin. 2021. Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. doi:10.1016/j.jsmc.2021.02.012 PubMed
- [5] Marc J Kaufman et al.. Neurosci Biobehav Rev. 2019. Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? doi:10.1016/j.neubiorev.2019.02.014 PubMed
- [6] Eric S Rawson et al.. Int J Sport Nutr Exerc Metab. 2018. Dietary Supplements for Health, Adaptation, and Recovery in Athletes. doi:10.1123/ijsnem.2017-0340 PubMed
- [7] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
- [8] Lynn Marie Trotti et al.. Handb Clin Neurol. 2011. Restless legs syndrome. doi:10.1016/B978-0-444-52014-2.00047-1 PubMed
- [9] Birgit M Dietz et al.. Brain Res Mol Brain Res. 2005. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. doi:10.1016/j.molbrainres.2005.04.009 PubMed
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.