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N-Acetyl Cysteine para Depression-Related Cognitive Dysfunction

C Evidências Evidência limitada de estudos de pequena dimensão, mas existem alguns sinais positivos.

Research suggests NAC's glutamate modulation and glutathione restoration may help address cognitive aspects of depression. Evidence is emerging from several clinical studies exploring NAC as an adjunctive treatment.

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Conclusão

            
            
Research suggests NAC's glutamate modulation and glutathione restoration may help address cognitive aspects of depression. Evidence is emerging from several clinical studies exploring NAC as an adjunctive treatment.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: restless legs syndrome

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: None

            
        

        
        

            

                
                    Other
                
                
                n=24
                
                
                2 weeks
                
                
            

            
                N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
            
            

                
                Dose: NAC 100 mg/kg body weight orally daily for 14 days
                
                
                vs: Placebo
                
                
                
                Efeito: significant augmentation of antioxidants and reduction of prooxidants in old rats; downregulation of
                
                
                None
                
            

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Restless legs syndrome.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: quality of life
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: cardiovascular patients

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
            
            

                
                Dose: Valerian extract and valerenic acid
                
                
                vs: LSD binding
                
                
                Outcome: 5-HT5a receptor binding affinity
                
                
                Efeito: PE extract IC50 15.7 ng/ml (high affinity)
                
                
                None
                
            

            
            
População: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Estudos

    

    

        
400

        
Participantes

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Nota

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Sleep medicine clinics
                        2021
                        
                        14 citações
                        
                    

                

                
                

                    

                        
                            Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Neuroscience and biobehavioral …
                        2019
                        
                        45 citações
                        
                    

                

                
                

                    

                        
                            N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Canadian journal of …
                        2018
                        
                        37 citações
                        
                    

                

                
                

                    

                        
                            Restless legs syndrome.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Handbook of clinical …
                        2011
                        
                        8 citações
                        
                    

                

                
                

                    

                        
                            Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Brain research. Molecular …
                        2005
                        
                        160 citações
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosagens Comumente Utilizadas

                

                    
                    

                        
general:

                        
600-1,800 mg/day

                    

                    
                    

                        
neuroprotection:

                        
1,200-2,400 mg/day

                    

                    
                

                
                

                    Limite superior: Not established as supplement; 6,000+ mg/day used clinically (IV)
                

                
            

            

            
            

                
Dosagens Estudadas em Pesquisas

                

                    

                        
                            

                                Dosagem
                                Duração
                                Efeito
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                NAC 100 mg/kg body weight orally daily for 14 days
                                2 weeks
                                
                                    
                                    Positive
                                    
                                
                                24
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                Valerian extract and valerenic acid
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Melhor horário: On empty stomach; split into 2-3 doses; supplement zinc if using long-term
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efeitos Colaterais Relatados

                    
    
                        
                        
  • 
                            ⚠
                            Nausea and vomiting
                        
    • 
                        
                        
  • 
                            ⚠
                            Diarrhea
                        
    • 
                        
                        
  • 
                            ⚠
                            Unpleasant sulfur taste/smell
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare: bronchospasm (inhaled form)
                        
    • 
                        
                        
  • 
                            ⚠
                            Long-term use may deplete zinc stores
                        
    • 
                        
                    

                

                

                
                

                    
Interações Conhecidas

                    
    
                        
                        
  • 
                            ●
                            Nitroglycerin (may enhance hypotensive effects)
                        
    • 
                        
                        
  • 
                            ●
                            Activated charcoal (reduces NAC absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (theoretical interaction)
                        
    • 
                        
                    

                

                

                
                

                    

                        Ingestão máxima tolerável: Not established as supplement; 6,000+ mg/day used clinically (IV)
                    

                

                
            

            

                Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does N-Acetyl Cysteine help with Depression-Related Cognitive Dysfunction?
            
        
        

            Based on 6 studies with 400 participants, there is limited but promising evidence that N-Acetyl Cysteine may support Depression-Related Cognitive Dysfunction management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much N-Acetyl Cysteine should I take for Depression-Related Cognitive Dysfunction?
            
        
        

            Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of N-Acetyl Cysteine?
            
        
        

            Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for N-Acetyl Cysteine and Depression-Related Cognitive Dysfunction?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Outros ingredientes para Depression-Related Cognitive Dysfunction

                    

                        
                        
                            Omega-3 Fatty Acids (DHA/EPA)
                            B

                        
                        
                        
                            Vitamin D
                            C

                        
                        
                    

                

                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Sergi Ferré et al..
      Sleep Med Clin.
      2021.
      Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
      doi:10.1016/j.jsmc.2021.02.012
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Marc J Kaufman et al..
      Neurosci Biobehav Rev.
      2019.
      Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
      doi:10.1016/j.neubiorev.2019.02.014
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Geetika Garg et al..
      Can J Physiol Pharmacol.
      2018.
      N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
      doi:10.1139/cjpp-2018-0209
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Lynn Marie Trotti et al..
      Handb Clin Neurol.
      2011.
      Restless legs syndrome.
      doi:10.1016/B978-0-444-52014-2.00047-1
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Birgit M Dietz et al..
      Brain Res Mol Brain Res.
      2005.
      Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
      doi:10.1016/j.molbrainres.2005.04.009
      PubMed
    
    6. 
    
  















    

        Aviso Legal da FDA:
        Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.