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N-Acetyl Cysteine cho Depression-Related Cognitive Dysfunction

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Research suggests NAC's glutamate modulation and glutathione restoration may help address cognitive aspects of depression. Evidence is emerging from several clinical studies exploring NAC as an adjunctive treatment.

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Kết luận

            
            
Research suggests NAC's glutamate modulation and glutathione restoration may help address cognitive aspects of depression. Evidence is emerging from several clinical studies exploring NAC as an adjunctive treatment.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
            
            

                
                Dose: None
                
                
                so với: None
                
                
                Outcome: None
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: restless legs syndrome

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
            
            

                
                Dose: None
                
                
                so với: None
                
                
                Outcome: None
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: None

            
        

        
        

            

                
                    Other
                
                
                n=24
                
                
                2 weeks
                
                
            

            
                N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
            
            

                
                Dose: NAC 100 mg/kg body weight orally daily for 14 days
                
                
                so với: Placebo
                
                
                
                Hiệu quả: significant augmentation of antioxidants and reduction of prooxidants in old rats; downregulation of
                
                
                None
                
            

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Restless legs syndrome.
            
            

                
                Dose: None
                
                
                so với: None
                
                
                Outcome: quality of life
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: cardiovascular patients

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
            
            

                
                Dose: Valerian extract and valerenic acid
                
                
                so với: LSD binding
                
                
                Outcome: 5-HT5a receptor binding affinity
                
                
                Hiệu quả: PE extract IC50 15.7 ng/ml (high affinity)
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Nghiên cứu

    

    

        
400

        
Người tham gia

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Xếp hạng

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Sleep medicine clinics
                        2021
                        
                        14 trích dẫn
                        
                    

                

                
                

                    

                        
                            Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Neuroscience and biobehavioral …
                        2019
                        
                        45 trích dẫn
                        
                    

                

                
                

                    

                        
                            N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Canadian journal of …
                        2018
                        
                        37 trích dẫn
                        
                    

                

                
                

                    

                        
                            Restless legs syndrome.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Handbook of clinical …
                        2011
                        
                        8 trích dẫn
                        
                    

                

                
                

                    

                        
                            Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Brain research. Molecular …
                        2005
                        
                        160 trích dẫn
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Liều lượng thường dùng

                

                    
                    

                        
general:

                        
600-1,800 mg/day

                    

                    
                    

                        
neuroprotection:

                        
1,200-2,400 mg/day

                    

                    
                

                
                

                    Giới hạn trên: Not established as supplement; 6,000+ mg/day used clinically (IV)
                

                
            

            

            
            

                
Liều lượng đã nghiên cứu

                

                    

                        
                            

                                Liều lượng
                                Thời gian
                                Hiệu quả
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                NAC 100 mg/kg body weight orally daily for 14 days
                                2 weeks
                                
                                    
                                    Positive
                                    
                                
                                24
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                Valerian extract and valerenic acid
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Thời điểm dùng tốt nhất: On empty stomach; split into 2-3 doses; supplement zinc if using long-term
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Tác dụng phụ đã được báo cáo

                    
    
                        
                        
  • 
                            ⚠
                            Nausea and vomiting
                        
    • 
                        
                        
  • 
                            ⚠
                            Diarrhea
                        
    • 
                        
                        
  • 
                            ⚠
                            Unpleasant sulfur taste/smell
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare: bronchospasm (inhaled form)
                        
    • 
                        
                        
  • 
                            ⚠
                            Long-term use may deplete zinc stores
                        
    • 
                        
                    

                

                

                
                

                    
Tương tác đã biết

                    
    
                        
                        
  • 
                            ●
                            Nitroglycerin (may enhance hypotensive effects)
                        
    • 
                        
                        
  • 
                            ●
                            Activated charcoal (reduces NAC absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (theoretical interaction)
                        
    • 
                        
                    

                

                

                
                

                    

                        Mức hấp thụ tối đa cho phép: Not established as supplement; 6,000+ mg/day used clinically (IV)
                    

                

                
            

            

                Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does N-Acetyl Cysteine help with Depression-Related Cognitive Dysfunction?
            
        
        

            Based on 6 studies with 400 participants, there is limited but promising evidence that N-Acetyl Cysteine may support Depression-Related Cognitive Dysfunction management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much N-Acetyl Cysteine should I take for Depression-Related Cognitive Dysfunction?
            
        
        

            Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of N-Acetyl Cysteine?
            
        
        

            Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for N-Acetyl Cysteine and Depression-Related Cognitive Dysfunction?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Các thành phần khác cho Depression-Related Cognitive Dysfunction

                    

                        
                        
                            Omega-3 Fatty Acids (DHA/EPA)
                            B

                        
                        
                        
                            Vitamin D
                            C

                        
                        
                    

                

                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Sergi Ferré et al..
      Sleep Med Clin.
      2021.
      Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
      doi:10.1016/j.jsmc.2021.02.012
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Marc J Kaufman et al..
      Neurosci Biobehav Rev.
      2019.
      Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
      doi:10.1016/j.neubiorev.2019.02.014
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Geetika Garg et al..
      Can J Physiol Pharmacol.
      2018.
      N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
      doi:10.1139/cjpp-2018-0209
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Lynn Marie Trotti et al..
      Handb Clin Neurol.
      2011.
      Restless legs syndrome.
      doi:10.1016/B978-0-444-52014-2.00047-1
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Birgit M Dietz et al..
      Brain Res Mol Brain Res.
      2005.
      Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
      doi:10.1016/j.molbrainres.2005.04.009
      PubMed
    
    6. 
    
  















    

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