Vitamin D cho Depression-Related Cognitive Dysfunction
C Bằng chứng Bằng chứng hạn chế từ các nghiên cứu nhỏ, nhưng có một số tín hiệu tích cực.Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.
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C
Kết luận
Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
so với: None
Outcome: Cognitive impairment risk
Hiệu quả: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
Đối tượng nghiên cứu: Elderly participants aged 60+ from NHANES 2011-2014
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
so với: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
Hiệu quả: None
None
Đối tượng nghiên cứu: Pregnant women (review)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
so với: Control
Outcome: Cognitive function
Hiệu quả: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
Đối tượng nghiên cứu: Patients with mild cognitive impairment
Other
Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis.
Dose: 75 mg
so với: None
Outcome: Body weight
Hiệu quả: None
P < 0.05
Đối tượng nghiên cứu: Rat model
Controlled Clinical Trial
Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.
Dose: None
so với: None
Outcome: neuroprotection
Hiệu quả: None
None
Đối tượng nghiên cứu: None
RCT
n=65
36 weeks
Double-blind
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: …
Dose: 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi
so với: Placebo
Hiệu quả: significant improvement in cognitive fatigue (FIS-40); p = 0.0338
0.0338
Key Statistics
12
Nghiên cứu
2000
Người tham gia
↑
Positive
C
Xếp hạng
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 trích dẫn
European journal of …
2024
16 trích dẫn
Poultry science
2024
9 trích dẫn
Nutrients
2023
9 trích dẫn
Frontiers in neuroscience
2023
5 trích dẫn
Journal of cosmetic …
2023
3 trích dẫn
Nutrition and health
2020
4 trích dẫn
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 trích dẫn
The journal of …
2017
75 trích dẫn
The journal of …
2015
25 trích dẫn
[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].
Review
Der Internist
2015
3 trích dẫn
European journal of …
2012
225 trích dẫn
Evidence report/technology assessment
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 600-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day
Giới hạn trên: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 75 mg | -- | Neutral | -- |
| None | -- | Positive | -- |
| 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi | 36 weeks | Positive | 65 |
| None | -- | Negative | 90 |
| 50000 IU/week | 9 weeks | Positive | 619 |
Thời điểm dùng tốt nhất: With meals containing fat; morning preferred
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Hypercalcemia at very high doses
- ⚠ Nausea and vomiting
- ⚠ Kidney stones (rare, high doses)
- ⚠ Weakness and fatigue
Tương tác đã biết
- ● Corticosteroids (reduce calcium absorption)
- ● Statins (both affect cholesterol pathways)
- ● Thiazide diuretics (additive calcium retention)
- ● Weight loss drugs (may reduce vitamin D absorption)
Mức hấp thụ tối đa cho phép: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Vitamin D help with Depression-Related Cognitive Dysfunction?
Based on 12 studies with 2,000 participants, there is limited but promising evidence that Vitamin D may support Depression-Related Cognitive Dysfunction management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for Depression-Related Cognitive Dysfunction?
Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Depression-Related Cognitive Dysfunction?
We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Depression-Related Cognitive Dysfunction
Vitamin D cho các tình trạng khác
References
- [1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
- [4] Guangtian Cao et al.. Poult Sci. 2024. Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. doi:10.1016/j.psj.2024.103966 PubMed
- [5] Marcos Lacasa et al.. Nutrients. 2023. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.3390/nu15214504 PubMed
- [6] Nijee S Luthra et al.. Front Neurosci. 2023. Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. doi:10.3389/fnins.2023.1228444 PubMed
- [7] N M Dawoud et al.. J Cosmet Dermatol. 2023. Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … doi:10.1111/jocd.15725 PubMed
- [8] Elahe Allahyari et al.. Nutr Health. 2020. The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. doi:10.1177/0260106020937190 PubMed
- [9] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [10] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [11] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [12] D Polivka et al.. Internist (Berl). 2015. [Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. doi:10.1007/s00108-015-3778-9 PubMed
- [13] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [14] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
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