Vitamin D के लिए Depression-Related Cognitive Dysfunction
C साक्ष्य की तुलना करें छोटे अध्ययनों से सीमित साक्ष्य उपलब्ध हैं, लेकिन कुछ सकारात्मक संकेत मौजूद हैं।Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.
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C
निष्कर्ष
Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
बनाम: None
Outcome: Cognitive impairment risk
प्रभाव: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
जनसंख्या: Elderly participants aged 60+ from NHANES 2011-2014
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
बनाम: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
प्रभाव: None
None
जनसंख्या: Pregnant women (review)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
बनाम: Control
Outcome: Cognitive function
प्रभाव: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
जनसंख्या: Patients with mild cognitive impairment
Other
Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis.
Dose: 75 mg
बनाम: None
Outcome: Body weight
प्रभाव: None
P < 0.05
जनसंख्या: Rat model
Controlled Clinical Trial
Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.
Dose: None
बनाम: None
Outcome: neuroprotection
प्रभाव: None
None
जनसंख्या: None
RCT
n=65
36 weeks
Double-blind
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: …
Dose: 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi
बनाम: Placebo
प्रभाव: significant improvement in cognitive fatigue (FIS-40); p = 0.0338
0.0338
Key Statistics
12
अध्ययन
2000
प्रतिभागी
↑
Positive
C
ग्रेड
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 उद्धरण
European journal of …
2024
16 उद्धरण
Poultry science
2024
9 उद्धरण
Nutrients
2023
9 उद्धरण
Frontiers in neuroscience
2023
5 उद्धरण
Journal of cosmetic …
2023
3 उद्धरण
Nutrition and health
2020
4 उद्धरण
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 उद्धरण
The journal of …
2017
75 उद्धरण
The journal of …
2015
25 उद्धरण
[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].
Review
Der Internist
2015
3 उद्धरण
European journal of …
2012
225 उद्धरण
Evidence report/technology assessment
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 600-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day
अधिकतम सीमा: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 75 mg | -- | Neutral | -- |
| None | -- | Positive | -- |
| 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi | 36 weeks | Positive | 65 |
| None | -- | Negative | 90 |
| 50000 IU/week | 9 weeks | Positive | 619 |
सेवन का सर्वोत्तम समय: With meals containing fat; morning preferred
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Hypercalcemia at very high doses
- ⚠ Nausea and vomiting
- ⚠ Kidney stones (rare, high doses)
- ⚠ Weakness and fatigue
ज्ञात अंतःक्रियाएँ
- ● Corticosteroids (reduce calcium absorption)
- ● Statins (both affect cholesterol pathways)
- ● Thiazide diuretics (additive calcium retention)
- ● Weight loss drugs (may reduce vitamin D absorption)
सहनीय अधिकतम सेवन: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Vitamin D help with Depression-Related Cognitive Dysfunction?
Based on 12 studies with 2,000 participants, there is limited but promising evidence that Vitamin D may support Depression-Related Cognitive Dysfunction management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for Depression-Related Cognitive Dysfunction?
Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Depression-Related Cognitive Dysfunction?
We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री Depression-Related Cognitive Dysfunction
Vitamin D अन्य स्वास्थ्य स्थितियों के लिए
References
- [1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
- [4] Guangtian Cao et al.. Poult Sci. 2024. Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. doi:10.1016/j.psj.2024.103966 PubMed
- [5] Marcos Lacasa et al.. Nutrients. 2023. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.3390/nu15214504 PubMed
- [6] Nijee S Luthra et al.. Front Neurosci. 2023. Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. doi:10.3389/fnins.2023.1228444 PubMed
- [7] N M Dawoud et al.. J Cosmet Dermatol. 2023. Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … doi:10.1111/jocd.15725 PubMed
- [8] Elahe Allahyari et al.. Nutr Health. 2020. The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. doi:10.1177/0260106020937190 PubMed
- [9] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [10] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [11] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [12] D Polivka et al.. Internist (Berl). 2015. [Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. doi:10.1007/s00108-015-3778-9 PubMed
- [13] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [14] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।