Vitamin D 用于 抑郁相关认知功能障碍
C 证据 来自小型研究的证据有限，但存在一些积极信号。Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'braincited.com';
const params = 'ingredient\u003Dvitamin\u002Dd\u0026condition\u003Ddepression\u002Dcognitive';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
C
结论
Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs: None
Outcome: Cognitive impairment risk
效果: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
研究人群: Elderly participants aged 60+ from NHANES 2011-2014
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
vs: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
效果: None
None
研究人群: Pregnant women (review)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
vs: Control
Outcome: Cognitive function
效果: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
研究人群: Patients with mild cognitive impairment
Other
Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis.
Dose: 75 mg
vs: None
Outcome: Body weight
效果: None
P < 0.05
研究人群: Rat model
Controlled Clinical Trial
Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.
Dose: None
vs: None
Outcome: neuroprotection
效果: None
None
研究人群: None
RCT
n=65
36 weeks
Double-blind
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: …
Dose: 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi
vs: Placebo
效果: significant improvement in cognitive fatigue (FIS-40); p = 0.0338
0.0338
Key Statistics
12
研究数量
2000
受试者
↑
Positive
C
等级
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 次引用
European journal of …
2024
16 次引用
Poultry science
2024
9 次引用
Nutrients
2023
9 次引用
Frontiers in neuroscience
2023
5 次引用
Journal of cosmetic …
2023
3 次引用
Nutrition and health
2020
4 次引用
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 次引用
The journal of …
2017
75 次引用
The journal of …
2015
25 次引用
[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].
Review
Der Internist
2015
3 次引用
European journal of …
2012
225 次引用
Evidence report/technology assessment
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day
上限： 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 75 mg | -- | Neutral | -- |
| None | -- | Positive | -- |
| 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi | 36 weeks | Positive | 65 |
| None | -- | Negative | 90 |
| 50000 IU/week | 9 weeks | Positive | 619 |
最佳服用时间： With meals containing fat; morning preferred
Safety & Side Effects
已报告的副作用
- ⚠ Hypercalcemia at very high doses
- ⚠ Nausea and vomiting
- ⚠ Kidney stones (rare, high doses)
- ⚠ Weakness and fatigue
已知相互作用
- ● Corticosteroids (reduce calcium absorption)
- ● Statins (both affect cholesterol pathways)
- ● Thiazide diuretics (additive calcium retention)
- ● Weight loss drugs (may reduce vitamin D absorption)
可耐受最高摄入量： 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin D help with 抑郁相关认知功能障碍?
Based on 12 studies with 2,000 participants, there is limited but promising evidence that Vitamin D may support 抑郁相关认知功能障碍 management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for 抑郁相关认知功能障碍?
Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and 抑郁相关认知功能障碍?
We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 抑郁相关认知功能障碍
Vitamin D 用于其他健康状况
References
- [1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
- [2] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
- [3] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
- [4] Guangtian Cao et al.. Poult Sci. 2024. Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. doi:10.1016/j.psj.2024.103966 PubMed
- [5] Marcos Lacasa et al.. Nutrients. 2023. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.3390/nu15214504 PubMed
- [6] Nijee S Luthra et al.. Front Neurosci. 2023. Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. doi:10.3389/fnins.2023.1228444 PubMed
- [7] N M Dawoud et al.. J Cosmet Dermatol. 2023. Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … doi:10.1111/jocd.15725 PubMed
- [8] Elahe Allahyari et al.. Nutr Health. 2020. The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. doi:10.1177/0260106020937190 PubMed
- [9] Anne Ws Rutjes et al.. Cochrane Database Syst Rev. 2018. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. doi:10.1002/14651858.CD011906.pub2 PubMed
- [10] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
- [11] D Krause et al.. J Nutr Health Aging. 2015. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. doi:10.1007/s12603-015-0539-3 PubMed
- [12] D Polivka et al.. Internist (Berl). 2015. [Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. doi:10.1007/s00108-015-3778-9 PubMed
- [13] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [14] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。