Omega-3 Fatty Acids (DHA/EPA) 用于 抑郁相关认知功能障碍
B 证据 至少一项随机试验支持这一结论，结果基本一致。Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
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B
结论
Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
Key Study Findings
Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: narrative review of ashwagandha clinical trials and basic research (1994-present)
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
vs: Placebo
效果: None
None
Review
[Pharmacotherapies for insomnia].
Dose: Z-drugs, melatonin, orexin antagonists
vs: None
Outcome: Insomnia treatment efficacy and safety
效果: None
None
研究人群: Adults with chronic insomnia
In Vitro
Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy.
Dose: Cannabidiol (CBD)
vs: Vehicle control
Outcome: Oxytocin and vasopressin gene expression
效果: None
None
研究人群: EAE mouse model (multiple sclerosis)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
vs: Control
Outcome: Cognitive function
效果: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
研究人群: Patients with mild cognitive impairment
Controlled Clinical Trial
Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice …
Dose: 5 g/kg or 10 g/kg (as VF)
vs: Caffeine-induced insomnia without VF
Outcome: Sleep latency and duration (pentobarbital-induced)
效果: None
None
研究人群: Caffeine-induced insomnia model mice
Key Statistics
15
研究数量
2500
受试者
↑
Positive
B
等级
Referenced Papers
Nutrients
2026
Journal of ethnopharmacology
2025
9 次引用
European journal of …
2024
16 次引用
Biomedicines
2024
3 次引用
La Revue du …
2024
Preventive nutrition and …
2022
18 次引用
Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging.
Meta-Analysis
NeuroImage. Clinical
2022
14 次引用
Journal of ethnopharmacology
2022
8 次引用
BMJ open
2022
3 次引用
Restless legs syndrome.
Review
Nature reviews. Disease …
2021
163 次引用
Journal of ethnopharmacology
2021
69 次引用
Journal of ethnopharmacology
2021
16 次引用
The Senior care …
2021
2 次引用
EBioMedicine
2020
107 次引用
Journal of ethnopharmacology
2020
85 次引用
Journal of clinical …
2020
17 次引用
Journal of psychiatric …
2019
46 次引用
Current neurology and …
2019
11 次引用
Sleep medicine
2017
95 次引用
The journal of …
2017
75 次引用
Current treatment options …
2017
56 次引用
Clinical therapeutics
2016
328 次引用
Molecular nutrition & …
2015
18 次引用
Pharmacotherapy
2007
117 次引用
Anesthesia and analgesia
2004
127 次引用
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 次引用
Influence of diethyl maleate and cysteine on tissue glutathione and growth in broiler chickens.
Other
Poultry science
1995
16 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 1,000-2,000 mg combined DHA/EPA per day
- cognitivesupport:
- 1,000-1,700 mg/day (optimal dose-response curve)
上限： 3,000 mg/day combined DHA/EPA (FDA GRAS)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
| Cannabidiol (CBD) | -- | Positive | -- |
| None | -- | Positive | -- |
| 5 g/kg or 10 g/kg (as VF) | -- | Positive | -- |
| 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) | -- | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间： With meals containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Fishy aftertaste or burping
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential increased bleeding time at very high doses
- ⚠ May lower blood pressure slightly
已知相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
可耐受最高摄入量： 3,000 mg/day combined DHA/EPA (FDA GRAS)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Omega-3 Fatty Acids (DHA/EPA) help with 抑郁相关认知功能障碍?
Based on 15 studies with 2,500 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support 抑郁相关认知功能障碍 management. Our evidence grade is B (Good Evidence).
How much Omega-3 Fatty Acids (DHA/EPA) should I take for 抑郁相关认知功能障碍?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and 抑郁相关认知功能障碍?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 2,500 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 抑郁相关认知功能障碍
Omega-3 Fatty Acids (DHA/EPA) 用于其他健康状况
References
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