Omega-3 Fatty Acids (DHA/EPA) 관련 Depression-Related Cognitive Dysfunction
BResearch suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
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B
결론
Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
Key Study Findings
Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: narrative review of ashwagandha clinical trials and basic research (1994-present)
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
vs: Placebo
효과: None
None
Review
[Pharmacotherapies for insomnia].
Dose: Z-drugs, melatonin, orexin antagonists
vs: None
Outcome: Insomnia treatment efficacy and safety
효과: None
None
대상 집단: Adults with chronic insomnia
In Vitro
Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy.
Dose: Cannabidiol (CBD)
vs: Vehicle control
Outcome: Oxytocin and vasopressin gene expression
효과: None
None
대상 집단: EAE mouse model (multiple sclerosis)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
vs: Control
Outcome: Cognitive function
효과: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
대상 집단: Patients with mild cognitive impairment
Controlled Clinical Trial
Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice …
Dose: 5 g/kg or 10 g/kg (as VF)
vs: Caffeine-induced insomnia without VF
Outcome: Sleep latency and duration (pentobarbital-induced)
효과: None
None
대상 집단: Caffeine-induced insomnia model mice
Key Statistics
15
연구
2500
참여자
↑
Positive
B
등급
Referenced Papers
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Journal of ethnopharmacology
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Journal of ethnopharmacology
2021
16 인용
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2021
2 인용
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2020
107 인용
Journal of ethnopharmacology
2020
85 인용
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2020
17 인용
Journal of psychiatric …
2019
46 인용
Current neurology and …
2019
11 인용
Sleep medicine
2017
95 인용
The journal of …
2017
75 인용
Current treatment options …
2017
56 인용
Clinical therapeutics
2016
328 인용
Molecular nutrition & …
2015
18 인용
Pharmacotherapy
2007
117 인용
Anesthesia and analgesia
2004
127 인용
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 인용
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Other
Poultry science
1995
16 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 1,000-2,000 mg combined DHA/EPA per day
- cognitivesupport:
- 1,000-1,700 mg/day (optimal dose-response curve)
상한량: 3,000 mg/day combined DHA/EPA (FDA GRAS)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
| Cannabidiol (CBD) | -- | Positive | -- |
| None | -- | Positive | -- |
| 5 g/kg or 10 g/kg (as VF) | -- | Positive | -- |
| 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) | -- | Positive | -- |
| None | -- | Mixed | -- |
권장 복용 시간: With meals containing fat for better absorption
Safety & Side Effects
보고된 부작용
- ⚠ Fishy aftertaste or burping
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential increased bleeding time at very high doses
- ⚠ May lower blood pressure slightly
알려진 상호작용
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
일일 최대 섭취 허용량: 3,000 mg/day combined DHA/EPA (FDA GRAS)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Omega-3 Fatty Acids (DHA/EPA) help with Depression-Related Cognitive Dysfunction?
Based on 15 studies with 2,500 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Depression-Related Cognitive Dysfunction management. Our evidence grade is B (Good Evidence).
How much Omega-3 Fatty Acids (DHA/EPA) should I take for Depression-Related Cognitive Dysfunction?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Depression-Related Cognitive Dysfunction?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 2,500 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Depression-Related Cognitive Dysfunction
Omega-3 Fatty Acids (DHA/EPA) 다른 건강 상태에 대한 근거
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.