Omega-3 Fatty Acids (DHA/EPA) для Depression-Related Cognitive Dysfunction
B Доказательства По меньшей мере одно рандомизированное исследование подтверждает это, с в целом согласованными результатами.Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
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B
Итог
Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
Key Study Findings
Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: narrative review of ashwagandha clinical trials and basic research (1994-present)
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
или: Placebo
Эффект: None
None
Review
[Pharmacotherapies for insomnia].
Dose: Z-drugs, melatonin, orexin antagonists
или: None
Outcome: Insomnia treatment efficacy and safety
Эффект: None
None
Популяция: Adults with chronic insomnia
In Vitro
Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy.
Dose: Cannabidiol (CBD)
или: Vehicle control
Outcome: Oxytocin and vasopressin gene expression
Эффект: None
None
Популяция: EAE mouse model (multiple sclerosis)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
или: Control
Outcome: Cognitive function
Эффект: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
Популяция: Patients with mild cognitive impairment
Controlled Clinical Trial
Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice …
Dose: 5 g/kg or 10 g/kg (as VF)
или: Caffeine-induced insomnia without VF
Outcome: Sleep latency and duration (pentobarbital-induced)
Эффект: None
None
Популяция: Caffeine-induced insomnia model mice
Key Statistics
15
Исследования
2500
Участники
↑
Positive
B
Оценка
Referenced Papers
Nutrients
2026
Journal of ethnopharmacology
2025
9 цитирований
European journal of …
2024
16 цитирований
Biomedicines
2024
3 цитирований
La Revue du …
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Preventive nutrition and …
2022
18 цитирований
Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging.
Meta-Analysis
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Journal of ethnopharmacology
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Restless legs syndrome.
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Journal of ethnopharmacology
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Journal of ethnopharmacology
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11 цитирований
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2017
75 цитирований
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2017
56 цитирований
Clinical therapeutics
2016
328 цитирований
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2015
18 цитирований
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2007
117 цитирований
Anesthesia and analgesia
2004
127 цитирований
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 цитирований
Influence of diethyl maleate and cysteine on tissue glutathione and growth in broiler chickens.
Other
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1995
16 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 1,000-2,000 mg combined DHA/EPA per day
- cognitivesupport:
- 1,000-1,700 mg/day (optimal dose-response curve)
Верхний предел: 3,000 mg/day combined DHA/EPA (FDA GRAS)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
| Cannabidiol (CBD) | -- | Positive | -- |
| None | -- | Positive | -- |
| 5 g/kg or 10 g/kg (as VF) | -- | Positive | -- |
| 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) | -- | Positive | -- |
| None | -- | Mixed | -- |
Лучшее время приёма: With meals containing fat for better absorption
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Fishy aftertaste or burping
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential increased bleeding time at very high doses
- ⚠ May lower blood pressure slightly
Известные взаимодействия
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
Допустимый верхний уровень потребления: 3,000 mg/day combined DHA/EPA (FDA GRAS)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Omega-3 Fatty Acids (DHA/EPA) help with Depression-Related Cognitive Dysfunction?
Based on 15 studies with 2,500 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Depression-Related Cognitive Dysfunction management. Our evidence grade is B (Good Evidence).
How much Omega-3 Fatty Acids (DHA/EPA) should I take for Depression-Related Cognitive Dysfunction?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Depression-Related Cognitive Dysfunction?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 2,500 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Depression-Related Cognitive Dysfunction
Omega-3 Fatty Acids (DHA/EPA) для других состояний
References
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