Omega-3 Fatty Acids (DHA/EPA) untuk Depression-Related Cognitive Dysfunction
BResearch suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
Kesimpulan
Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
Key Study Findings
Populasi: narrative review of ashwagandha clinical trials and basic research (1994-present)
Populasi: Adults with chronic insomnia
Populasi: EAE mouse model (multiple sclerosis)
Populasi: Patients with mild cognitive impairment
Populasi: Caffeine-induced insomnia model mice
Key Statistics
15
Studi
2500
Peserta
Positive
Peringkat
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 1,000-2,000 mg combined DHA/EPA per day
- cognitivesupport:
- 1,000-1,700 mg/day (optimal dose-response curve)
Batas atas: 3,000 mg/day combined DHA/EPA (FDA GRAS)
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
| Cannabidiol (CBD) | -- | Positive | -- |
| None | -- | Positive | -- |
| 5 g/kg or 10 g/kg (as VF) | -- | Positive | -- |
| 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) | -- | Positive | -- |
| None | -- | Mixed | -- |
Waktu terbaik diminum: With meals containing fat for better absorption
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Fishy aftertaste or burping
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential increased bleeding time at very high doses
- ⚠ May lower blood pressure slightly
Interaksi yang Diketahui
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
Asupan atas yang dapat ditoleransi: 3,000 mg/day combined DHA/EPA (FDA GRAS)
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Omega-3 Fatty Acids (DHA/EPA) help with Depression-Related Cognitive Dysfunction?
How much Omega-3 Fatty Acids (DHA/EPA) should I take for Depression-Related Cognitive Dysfunction?
Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?
How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Depression-Related Cognitive Dysfunction?
Related Evidence
Bahan lain untuk Depression-Related Cognitive Dysfunction
Omega-3 Fatty Acids (DHA/EPA) untuk kondisi lain
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