Omega-3 Fatty Acids (DHA/EPA) ： Depression-Related Cognitive Dysfunction
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
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B
結論
Research suggests fish oil supplements may help support memory function and are also associated with improved outcomes in people experiencing depression-related cognitive symptoms.
Key Study Findings
Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: narrative review of ashwagandha clinical trials and basic research (1994-present)
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
vs: Placebo
効果: None
None
Review
[Pharmacotherapies for insomnia].
Dose: Z-drugs, melatonin, orexin antagonists
vs: None
Outcome: Insomnia treatment efficacy and safety
効果: None
None
対象集団: Adults with chronic insomnia
In Vitro
Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy.
Dose: Cannabidiol (CBD)
vs: Vehicle control
Outcome: Oxytocin and vasopressin gene expression
効果: None
None
対象集団: EAE mouse model (multiple sclerosis)
Meta-Analysis
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …
Dose: None
vs: Control
Outcome: Cognitive function
効果: SMD = 0.58, 95% CI = [0.20, 0.96]
P = 0.003
対象集団: Patients with mild cognitive impairment
Controlled Clinical Trial
Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice …
Dose: 5 g/kg or 10 g/kg (as VF)
vs: Caffeine-induced insomnia without VF
Outcome: Sleep latency and duration (pentobarbital-induced)
効果: None
None
対象集団: Caffeine-induced insomnia model mice
Key Statistics
15
研究数
2500
参加者数
↑
Positive
B
グレード
Referenced Papers
Nutrients
2026
Journal of ethnopharmacology
2025
9 件の引用
European journal of …
2024
16 件の引用
Biomedicines
2024
3 件の引用
La Revue du …
2024
Preventive nutrition and …
2022
18 件の引用
Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging.
Meta-Analysis
NeuroImage. Clinical
2022
14 件の引用
Journal of ethnopharmacology
2022
8 件の引用
BMJ open
2022
3 件の引用
Restless legs syndrome.
Review
Nature reviews. Disease …
2021
163 件の引用
Journal of ethnopharmacology
2021
69 件の引用
Journal of ethnopharmacology
2021
16 件の引用
The Senior care …
2021
2 件の引用
EBioMedicine
2020
107 件の引用
Journal of ethnopharmacology
2020
85 件の引用
Journal of clinical …
2020
17 件の引用
Journal of psychiatric …
2019
46 件の引用
Current neurology and …
2019
11 件の引用
Sleep medicine
2017
95 件の引用
The journal of …
2017
75 件の引用
Current treatment options …
2017
56 件の引用
Clinical therapeutics
2016
328 件の引用
Molecular nutrition & …
2015
18 件の引用
Pharmacotherapy
2007
117 件の引用
Anesthesia and analgesia
2004
127 件の引用
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 件の引用
Influence of diethyl maleate and cysteine on tissue glutathione and growth in broiler chickens.
Other
Poultry science
1995
16 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 1,000-2,000 mg combined DHA/EPA per day
- cognitivesupport:
- 1,000-1,700 mg/day (optimal dose-response curve)
上限量： 3,000 mg/day combined DHA/EPA (FDA GRAS)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
| Cannabidiol (CBD) | -- | Positive | -- |
| None | -- | Positive | -- |
| 5 g/kg or 10 g/kg (as VF) | -- | Positive | -- |
| 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) | -- | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals containing fat for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Fishy aftertaste or burping
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential increased bleeding time at very high doses
- ⚠ May lower blood pressure slightly
既知の相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
耐容上限摂取量： 3,000 mg/day combined DHA/EPA (FDA GRAS)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Omega-3 Fatty Acids (DHA/EPA) help with Depression-Related Cognitive Dysfunction?
Based on 15 studies with 2,500 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Depression-Related Cognitive Dysfunction management. Our evidence grade is B (Good Evidence).
How much Omega-3 Fatty Acids (DHA/EPA) should I take for Depression-Related Cognitive Dysfunction?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Depression-Related Cognitive Dysfunction?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 2,500 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Depression-Related Cognitive Dysfunction
Omega-3 Fatty Acids (DHA/EPA) 他の症状・状態について
References
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