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N-Acetyl Cysteine 관련 우울증 관련 인지 기능 장애

C 근거 소규모 연구에서의 근거는 제한적이지만, 일부 긍정적인 신호가 존재합니다.

Research suggests NAC's glutamate modulation and glutathione restoration may help address cognitive aspects of depression. Evidence is emerging from several clinical studies exploring NAC as an adjunctive treatment.

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            C

        

        

            
결론

            
            
Research suggests NAC's glutamate modulation and glutathione restoration may help address cognitive aspects of depression. Evidence is emerging from several clinical studies exploring NAC as an adjunctive treatment.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                효과: None
                
                
                None
                
            

            
            
대상 집단: restless legs syndrome

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                효과: None
                
                
                None
                
            

            
            
대상 집단: None

            
        

        
        

            

                
                    Other
                
                
                n=24
                
                
                2 weeks
                
                
            

            
                N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
            
            

                
                Dose: NAC 100 mg/kg body weight orally daily for 14 days
                
                
                vs: Placebo
                
                
                
                효과: significant augmentation of antioxidants and reduction of prooxidants in old rats; downregulation of
                
                
                None
                
            

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Restless legs syndrome.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: quality of life
                
                
                효과: None
                
                
                None
                
            

            
            
대상 집단: cardiovascular patients

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
            
            

                
                Dose: Valerian extract and valerenic acid
                
                
                vs: LSD binding
                
                
                Outcome: 5-HT5a receptor binding affinity
                
                
                효과: PE extract IC50 15.7 ng/ml (high affinity)
                
                
                None
                
            

            
            
대상 집단: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
연구

    

    

        
400

        
참여자

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
등급

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Sleep medicine clinics
                        2021
                        
                        14 인용
                        
                    

                

                
                

                    

                        
                            Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Neuroscience and biobehavioral …
                        2019
                        
                        45 인용
                        
                    

                

                
                

                    

                        
                            N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Canadian journal of …
                        2018
                        
                        37 인용
                        
                    

                

                
                

                    

                        
                            Restless legs syndrome.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Handbook of clinical …
                        2011
                        
                        8 인용
                        
                    

                

                
                

                    

                        
                            Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Brain research. Molecular …
                        2005
                        
                        160 인용
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
일반적으로 사용되는 용량

                

                    
                    

                        
general:

                        
600-1,800 mg/day

                    

                    
                    

                        
neuroprotection:

                        
1,200-2,400 mg/day

                    

                    
                

                
                

                    상한량: Not established as supplement; 6,000+ mg/day used clinically (IV)
                

                
            

            

            
            

                
연구에서 사용된 용량

                

                    

                        
                            

                                용량
                                기간
                                효과
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                NAC 100 mg/kg body weight orally daily for 14 days
                                2 weeks
                                
                                    
                                    Positive
                                    
                                
                                24
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                Valerian extract and valerenic acid
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                권장 복용 시간: On empty stomach; split into 2-3 doses; supplement zinc if using long-term
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
보고된 부작용

                    
    
                        
                        
  • 
                            ⚠
                            Nausea and vomiting
                        
    • 
                        
                        
  • 
                            ⚠
                            Diarrhea
                        
    • 
                        
                        
  • 
                            ⚠
                            Unpleasant sulfur taste/smell
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare: bronchospasm (inhaled form)
                        
    • 
                        
                        
  • 
                            ⚠
                            Long-term use may deplete zinc stores
                        
    • 
                        
                    

                

                

                
                

                    
알려진 상호작용

                    
    
                        
                        
  • 
                            ●
                            Nitroglycerin (may enhance hypotensive effects)
                        
    • 
                        
                        
  • 
                            ●
                            Activated charcoal (reduces NAC absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (theoretical interaction)
                        
    • 
                        
                    

                

                

                
                

                    

                        일일 최대 섭취 허용량: Not established as supplement; 6,000+ mg/day used clinically (IV)
                    

                

                
            

            

                건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does N-Acetyl Cysteine help with 우울증 관련 인지 기능 장애?
            
        
        

            Based on 6 studies with 400 participants, there is limited but promising evidence that N-Acetyl Cysteine may support 우울증 관련 인지 기능 장애 management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much N-Acetyl Cysteine should I take for 우울증 관련 인지 기능 장애?
            
        
        

            Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of N-Acetyl Cysteine?
            
        
        

            Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for N-Acetyl Cysteine and 우울증 관련 인지 기능 장애?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
관련 다른 성분: 우울증 관련 인지 기능 장애

                    

                        
                        
                            Omega-3 Fatty Acids (DHA/EPA)
                            B

                        
                        
                        
                            Vitamin D
                            C

                        
                        
                    

                

                

                
                

                    
N-Acetyl Cysteine 다른 건강 상태에 대한 근거

                    

                        
                        
                            산화 스트레스 및 신경염증
                            B

                        
                        
                        
                            뇌진탕 후 인지 증상
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Sergi Ferré et al..
      Sleep Med Clin.
      2021.
      Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
      doi:10.1016/j.jsmc.2021.02.012
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Marc J Kaufman et al..
      Neurosci Biobehav Rev.
      2019.
      Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
      doi:10.1016/j.neubiorev.2019.02.014
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Geetika Garg et al..
      Can J Physiol Pharmacol.
      2018.
      N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
      doi:10.1139/cjpp-2018-0209
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Lynn Marie Trotti et al..
      Handb Clin Neurol.
      2011.
      Restless legs syndrome.
      doi:10.1016/B978-0-444-52014-2.00047-1
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Birgit M Dietz et al..
      Brain Res Mol Brain Res.
      2005.
      Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
      doi:10.1016/j.molbrainres.2005.04.009
      PubMed
    
    6. 
    
  















    

        FDA 면책 조항:
        이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.