N-Acetyl Cysteine ： Post-Concussion Cognitive Symptoms
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.
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B
結論
NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.
Key Study Findings
Randomized Controlled Trial
n=50
Open-label
Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With …
Dose: None
vs: waitlist control (standard of care)
Outcome: resting-state functional connectivity and cognitive-affective symptoms
効果: None
p<0.05
対象集団: patients with chronic post-concussion syndrome for at least 3 months
Review
Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols.
Dose: None
vs: None
Outcome: TBI prevention and neuroprotection
効果: None
None
対象集団: Individuals with or at risk for TBI
Controlled Clinical Trial
n=65
4 weeks
Open-label
N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study.
Dose: None
vs: Standard care alone
Outcome: RPQ postconcussion symptom severity
効果: RPQ day 7: 2 vs 10; day 30: 0 vs 4
p=0.004 (day 7); p=0.021 (day
対象集団: Elderly patients (>=60y) with mild TBI
Review
Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: restless legs syndrome
Review
Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Dietary Supplements for Health, Adaptation, and Recovery in Athletes.
Dose: None
vs: None
Outcome: Health, adaptation, and recovery in athletes
効果: None
None
対象集団: Athletes
Key Statistics
6
研究数
400
参加者数
↑
Positive
B
グレード
Referenced Papers
The Journal of …
None
Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols.
Review
Nutrients
2024
22 件の引用
The journal of …
2022
7 件の引用
Sleep medicine clinics
2021
14 件の引用
Neuroscience and biobehavioral …
2019
45 件の引用
International journal of …
2018
165 件の引用
N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
Other
Canadian journal of …
2018
37 件の引用
Restless legs syndrome.
Review
Handbook of clinical …
2011
8 件の引用
Brain research. Molecular …
2005
160 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 600-1,800 mg/day
- neuroprotection:
- 1,200-2,400 mg/day
上限量： Not established as supplement; 6,000+ mg/day used clinically (IV)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 50 |
| None | -- | Positive | -- |
| None | 4 weeks | Positive | 65 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| NAC 100 mg/kg body weight orally daily for 14 days | 2 weeks | Positive | 24 |
| None | -- | Mixed | -- |
推奨摂取タイミング： On empty stomach; split into 2-3 doses; supplement zinc if using long-term
Safety & Side Effects
報告されている副作用
- ⚠ Nausea and vomiting
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/smell
- ⚠ Rare: bronchospasm (inhaled form)
- ⚠ Long-term use may deplete zinc stores
既知の相互作用
- ● Nitroglycerin (may enhance hypotensive effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (theoretical interaction)
耐容上限摂取量： Not established as supplement; 6,000+ mg/day used clinically (IV)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does N-Acetyl Cysteine help with Post-Concussion Cognitive Symptoms?
Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that N-Acetyl Cysteine may support Post-Concussion Cognitive Symptoms management. Our evidence grade is B (Good Evidence).
How much N-Acetyl Cysteine should I take for Post-Concussion Cognitive Symptoms?
Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine?
Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine and Post-Concussion Cognitive Symptoms?
We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
N-Acetyl Cysteine 他の症状・状態について
References
- [1] Daniel A Monti et al.. J Head Trauma Rehabil. Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With N-Acetyl Cysteine. doi:10.1097/HTR.0000000000000976 PubMed
- [2] Federica Conti et al.. Nutrients. 2024. Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols. doi:10.3390/nu16152430 PubMed
- [3] Ryan A Mcpherson et al.. J Trauma Acute Care Surg. 2022. N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study. doi:10.1097/TA.0000000000003639 PubMed
- [4] Sergi Ferré et al.. Sleep Med Clin. 2021. Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. doi:10.1016/j.jsmc.2021.02.012 PubMed
- [5] Marc J Kaufman et al.. Neurosci Biobehav Rev. 2019. Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? doi:10.1016/j.neubiorev.2019.02.014 PubMed
- [6] Eric S Rawson et al.. Int J Sport Nutr Exerc Metab. 2018. Dietary Supplements for Health, Adaptation, and Recovery in Athletes. doi:10.1123/ijsnem.2017-0340 PubMed
- [7] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
- [8] Lynn Marie Trotti et al.. Handb Clin Neurol. 2011. Restless legs syndrome. doi:10.1016/B978-0-444-52014-2.00047-1 PubMed
- [9] Birgit M Dietz et al.. Brain Res Mol Brain Res. 2005. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. doi:10.1016/j.molbrainres.2005.04.009 PubMed
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