N-Acetyl Cysteine ： Oxidative Stress & Neuroinflammation
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。As a glutathione precursor, NAC provides potent antioxidant and anti-inflammatory neuroprotection. Combined with selenium, research suggests synergistic protection against oxidative brain injury.
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B
結論
As a glutathione precursor, NAC provides potent antioxidant and anti-inflammatory neuroprotection. Combined with selenium, research suggests synergistic protection against oxidative brain injury.
Key Study Findings
Other
Executive Summary of the Vulvodynia Therapeutic Research Summit.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: expert consensus on therapeutics for provoked vestibulodynia
In Vitro
Neuroinflammation-Modulating Properties Combining Glutathione, N-Acetylcysteine, and Uridine Monophosphate in a Formulation Supplement: An In Vitro …
Dose: None
vs: ALA-based formula (SUPERALA CARNITINE)
Outcome: Neuroprotective and anti-inflammatory effects
効果: None
None
対象集団: 3D in vitro gut-peripheral nerve axis model
Review
Combination Supplement Therapy: A New Frontier in Treatment of Neurodegenerative Diseases.
Dose: None
vs: None
Outcome: Neurodegenerative disease pathology attenuation
効果: None
None
対象集団: Preclinical neurodegenerative disease models
Systematic Review
Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.
Dose: None
vs: None
Outcome: Antidepressant effects (neurotransmitter modulation)
効果: None
None
対象集団: Preclinical models
Review
Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment.
Dose: None
vs: None
Outcome: Inflammatory markers
効果: None
None
対象集団: Depression patients
Review
Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic …
Dose: Various phytochemicals
vs: None
Outcome: Neuroprotection in aging and neurodegeneration
効果: None
None
対象集団: Aging brain and NDD models (review)
Key Statistics
12
研究数
800
参加者数
↑
Positive
B
グレード
Referenced Papers
Obstetrics and gynecology
2026
Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.
Systematic Review
Molecular nutrition & …
2025
8 件の引用
Brain sciences
2025
The Journal of …
2025
Ecotoxicology and environmental …
2024
7 件の引用
Nutrients
2023
31 件の引用
The journal of …
2021
41 件の引用
Journal of fungi …
2021
14 件の引用
Sleep medicine clinics
2021
14 件の引用
Biomolecules
2020
28 件の引用
Neuroscience and biobehavioral …
2019
45 件の引用
N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
Other
Canadian journal of …
2018
37 件の引用
Medical hypotheses
2014
36 件の引用
Restless legs syndrome.
Review
Handbook of clinical …
2011
8 件の引用
Brain research. Molecular …
2005
160 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 600-1,800 mg/day
- neuroprotection:
- 1,200-2,400 mg/day
上限量： Not established as supplement; 6,000+ mg/day used clinically (IV)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： On empty stomach; split into 2-3 doses; supplement zinc if using long-term
Safety & Side Effects
報告されている副作用
- ⚠ Nausea and vomiting
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/smell
- ⚠ Rare: bronchospasm (inhaled form)
- ⚠ Long-term use may deplete zinc stores
既知の相互作用
- ● Nitroglycerin (may enhance hypotensive effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (theoretical interaction)
耐容上限摂取量： Not established as supplement; 6,000+ mg/day used clinically (IV)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does N-Acetyl Cysteine help with Oxidative Stress & Neuroinflammation?
Based on 12 studies with 800 participants, there is moderate evidence from clinical studies that N-Acetyl Cysteine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is B (Good Evidence).
How much N-Acetyl Cysteine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine?
Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Oxidative Stress & Neuroinflammation
N-Acetyl Cysteine 他の症状・状態について
References
- [1] Jill M Krapf et al.. Obstet Gynecol. 2026. Executive Summary of the Vulvodynia Therapeutic Research Summit. doi:10.1097/AOG.0000000000006118 PubMed
- [2] Pin Gong et al.. Mol Nutr Food Res. 2025. Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications. doi:10.1002/mnfr.70080 PubMed
- [3] Simone Mulè et al.. Brain Sci. 2025. Neuroinflammation-Modulating Properties Combining Glutathione, N-Acetylcysteine, and Uridine Monophosphate in a Formulation Supplement: An In Vitro Study. doi:10.3390/brainsci15121340 PubMed
- [4] Alexander Shtilbans. J Nutr. 2025. Combination Supplement Therapy: A New Frontier in Treatment of Neurodegenerative Diseases. doi:10.1016/j.tjnut.2025.07.004 PubMed
- [5] Yuyan Chen et al.. Ecotoxicol Environ Saf. 2024. Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment. doi:10.1016/j.ecoenv.2024.117411 PubMed
- [6] Hamid Mostafavi Abdolmaleky et al.. Nutrients. 2023. Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals. doi:10.3390/nu15153456 PubMed
- [7] Jonathan Paulo Agnes et al.. J Pain. 2021. Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation. doi:10.1016/j.jpain.2021.03.142 PubMed
- [8] Mihai-Vlad Valu et al.. J Fungi (Basel). 2021. Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment. doi:10.3390/jof7060477 PubMed
- [9] Sergi Ferré et al.. Sleep Med Clin. 2021. Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. doi:10.1016/j.jsmc.2021.02.012 PubMed
- [10] Mujtaba Aamir Bhat et al.. Biomolecules. 2020. Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases. doi:10.3390/biom10060863 PubMed
- [11] Marc J Kaufman et al.. Neurosci Biobehav Rev. 2019. Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? doi:10.1016/j.neubiorev.2019.02.014 PubMed
- [12] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
- [13] Alan D Strickland. Med Hypotheses. 2014. Prevention of cerebral palsy, autism spectrum disorder, and attention deficit-hyperactivity disorder. doi:10.1016/j.mehy.2014.02.003 PubMed
- [14] Lynn Marie Trotti et al.. Handb Clin Neurol. 2011. Restless legs syndrome. doi:10.1016/B978-0-444-52014-2.00047-1 PubMed
- [15] Birgit M Dietz et al.. Brain Res Mol Brain Res. 2005. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. doi:10.1016/j.molbrainres.2005.04.009 PubMed
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