Green Tea Extract (EGCG) ： Oxidative Stress & Neuroinflammation
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Research suggests EGCG inhibits beta-amyloid aggregation and provides antioxidant neuroprotection. Strong epidemiological data links regular green tea consumption to reduced cognitive decline risk.
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C
結論
Research suggests EGCG inhibits beta-amyloid aggregation and provides antioxidant neuroprotection. Strong epidemiological data links regular green tea consumption to reduced cognitive decline risk.
Key Study Findings
Review
Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: older adults and individuals with neurodegenerative disorders
Review
Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines.
Dose: None
vs: None
Outcome: ASD symptom management
効果: None
None
対象集団: Children with autism spectrum disorder
Review
Polyphenols and Alzheimer's Disease: A Review on Molecular and Therapeutic Insights With In Silico Support.
Dose: None
vs: None
Outcome: Neuroprotection in Alzheimer's disease
効果: None
None
対象集団: Alzheimer's disease (review with in silico)
Review
Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Other
5 weeks
Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60.
Dose: None
vs: None
Outcome: Cognitive function
効果: None
None
対象集団: Rat model
Review
Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic …
Dose: Various phytochemicals
vs: None
Outcome: Neuroprotection in aging and neurodegeneration
効果: None
None
対象集団: Aging brain and NDD models (review)
Key Statistics
10
研究数
800
参加者数
↑
Positive
C
グレード
Referenced Papers
Phytotherapy research : …
2026
Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection.
Review
Nutritional neuroscience
2025
14 件の引用
Food science & …
2025
4 件の引用
Alternative therapies in …
2025
Nutrients
2024
8 件の引用
Nutrients
2023
31 件の引用
Frontiers in pharmacology
2022
51 件の引用
Molecular neurobiology
2021
22 件の引用
Molecular nutrition & …
2021
18 件の引用
European journal of …
2020
91 件の引用
Neurochemistry international
2016
153 件の引用
The Journal of …
2014
33 件の引用
Evidence-based complementary and …
2012
93 件の引用
Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis.
Review
Clinical nutrition (Edinburgh, …
2009
52 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 250-500 mg/day EGCG
- viatea:
- 3-5 cups/day
上限量： 800 mg/day EGCG from supplements (hepatotoxicity risk above)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | 5 weeks | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 8 weeks | Positive | -- |
推奨摂取タイミング： Between meals; avoid on empty stomach
Safety & Side Effects
報告されている副作用
- ⚠ Liver toxicity at high doses (>800 mg EGCG/day)
- ⚠ Insomnia (caffeine content)
- ⚠ Gastrointestinal discomfort
- ⚠ Iron absorption reduction
既知の相互作用
- ● Iron supplements (tannins reduce absorption)
- ● Nadolol (reduces blood levels)
- ● Blood thinners (mild antiplatelet effect)
- ● MAO inhibitors (caffeine interaction)
耐容上限摂取量： 800 mg/day EGCG from supplements (hepatotoxicity risk above)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Green Tea Extract (EGCG) help with Oxidative Stress & Neuroinflammation?
Based on 10 studies with 800 participants, there is limited but promising evidence that Green Tea Extract (EGCG) may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Green Tea Extract (EGCG) should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 250-500 mg/day EGCG. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Green Tea Extract (EGCG)?
Reported side effects may include Liver toxicity at high doses (>800 mg EGCG/day), Insomnia (caffeine content), Gastrointestinal discomfort, Iron absorption reduction. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Green Tea Extract (EGCG) and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Oxidative Stress & Neuroinflammation
References
- [1] Lei Wang et al.. Phytother Res. 2026. Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function … doi:10.1002/ptr.70198 PubMed
- [2] Rarchita Sharma et al.. Nutr Neurosci. 2025. Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection. doi:10.1080/1028415X.2025.2469170 PubMed
- [3] Guifei Chen et al.. Food Sci Nutr. 2025. Polyphenols and Alzheimer's Disease: A Review on Molecular and Therapeutic Insights With In Silico Support. doi:10.1002/fsn3.70496 PubMed
- [4] Nasser M Aldekhail et al.. Altern Ther Health Med. 2025. Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines. PubMed
- [5] Silvia Tejada et al.. Nutrients. 2024. Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60. doi:10.3390/nu16030368 PubMed
- [6] Hamid Mostafavi Abdolmaleky et al.. Nutrients. 2023. Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals. doi:10.3390/nu15153456 PubMed
- [7] Yumin Wang et al.. Front Pharmacol. 2022. Epigallocatechin-3-gallate: A phytochemical as a promising drug candidate for the treatment of Parkinson's disease. doi:10.3389/fphar.2022.977521 PubMed
- [8] Belén Mollá et al.. Mol Neurobiol. 2021. Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model. doi:10.1007/s12035-021-02285-1 PubMed
- [9] Zhipeng Kan et al.. Mol Nutr Food Res. 2021. Green Tea Suppresses Amyloid β Levels and Alleviates Cognitive Impairment by Inhibiting APP Cleavage and Preventing Neurotoxicity in 5XFAD Mice. doi:10.1002/mnfr.202100626 PubMed
- [10] Danica Michaličková et al.. Eur J Pharmacol. 2020. Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis. doi:10.1016/j.ejphar.2020.172973 PubMed
- [11] Madhuri Venigalla et al.. Neurochem Int. 2016. Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease. doi:10.1016/j.neuint.2015.10.011 PubMed
- [12] Marcos H Okuda et al.. J Nutr Biochem. 2014. Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system. doi:10.1016/j.jnutbio.2014.05.012 PubMed
- [13] Kuo-Jen Wu et al.. Evid Based Complement Alternat Med. 2012. Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of … doi:10.1155/2012/163106 PubMed
- [14] Barkha P Patel et al.. Clin Nutr. 2009. Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis. doi:10.1016/j.clnu.2009.06.002 PubMed
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