Green Tea Extract (EGCG) for Oxidative Stress & Neuroinflammation
CResearch suggests EGCG inhibits beta-amyloid aggregation and provides antioxidant neuroprotection. Strong epidemiological data links regular green tea consumption to reduced cognitive decline risk.
The Bottom Line
Research suggests EGCG inhibits beta-amyloid aggregation and provides antioxidant neuroprotection. Strong epidemiological data links regular green tea consumption to reduced cognitive decline risk.
Key Study Findings
Population: older adults and individuals with neurodegenerative disorders
Population: Children with autism spectrum disorder
Population: Alzheimer's disease (review with in silico)
Population: None
Population: Rat model
Population: Aging brain and NDD models (review)
Key Statistics
10
Studies
800
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 250-500 mg/day EGCG
- viatea:
- 3-5 cups/day
Upper limit: 800 mg/day EGCG from supplements (hepatotoxicity risk above)
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | 5 weeks | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 8 weeks | Positive | -- |
Best taken: Between meals; avoid on empty stomach
Safety & Side Effects
Reported Side Effects
- ⚠ Liver toxicity at high doses (>800 mg EGCG/day)
- ⚠ Insomnia (caffeine content)
- ⚠ Gastrointestinal discomfort
- ⚠ Iron absorption reduction
Known Interactions
- ● Iron supplements (tannins reduce absorption)
- ● Nadolol (reduces blood levels)
- ● Blood thinners (mild antiplatelet effect)
- ● MAO inhibitors (caffeine interaction)
Tolerable upper intake: 800 mg/day EGCG from supplements (hepatotoxicity risk above)
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
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How much Green Tea Extract (EGCG) should I take for Oxidative Stress & Neuroinflammation?
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How strong is the evidence for Green Tea Extract (EGCG) and Oxidative Stress & Neuroinflammation?
Related Evidence
Other ingredients for Oxidative Stress & Neuroinflammation
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.