Alpha-Lipoic Acid for Oxidative Stress & Neuroinflammation
CA universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.
The Bottom Line
A universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.
Key Study Findings
Population: SH-SY5Y neuroblastoma cells with 6-OHDA-induced neurotoxicity (in vitro PD model)
Population: 18-month-old naturally aged C57BL/6 mice
Population: mice with spinal nerve ligation-induced neuropathic pain
Population: expert consensus on therapeutics for provoked vestibulodynia
Population: in vitro and in vivo epilepsy models
Population: male Sprague-Dawley rats
Key Statistics
8
Studies
500
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 300-600 mg/day
- cognitivesupport:
- 600-1,200 mg/day (R-ALA preferred)
Upper limit: 2,400 mg/day (highest dose in clinical trials)
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 100 mg/kg/day | 8 weeks | Positive | -- |
| 50, 100, and 200 mg/kg | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p. | 4 weeks | Positive | 24 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
Best taken: On empty stomach; 30 minutes before meals
Safety & Side Effects
Reported Side Effects
- ⚠ Gastrointestinal discomfort
- ⚠ Skin rash
- ⚠ Hypoglycemia (in diabetics)
- ⚠ Headache
Known Interactions
- ● Antidiabetic drugs (may enhance blood sugar lowering)
- ● Thyroid medications (may affect thyroid hormone levels)
- ● Chemotherapy agents (may reduce efficacy of some agents)
Tolerable upper intake: 2,400 mg/day (highest dose in clinical trials)
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
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Related Evidence
Other ingredients for Oxidative Stress & Neuroinflammation
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.