Alpha-Lipoic Acid 用于 Oxidative Stress & Neuroinflammation
CA universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.
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C
结论
A universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.
Key Study Findings
In Vitro
Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis …
Dose: None
vs: free alpha-lipoic acid
Outcome: neuroprotective efficacy against 6-OHDA-induced neurotoxicity
效果: None
None
研究人群: SH-SY5Y neuroblastoma cells with 6-OHDA-induced neurotoxicity (in vitro PD model)
Other
8 weeks
α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation.
Dose: 100 mg/kg/day
vs: untreated aged mice; D-galactose-induced senescent BV2 cells
Outcome: cognitive function (T maze behavioral tests)
效果: None
None
研究人群: 18-month-old naturally aged C57BL/6 mice
Other
Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.
Dose: 50, 100, and 200 mg/kg
vs: sham-operated controls
Outcome: mechanical and thermal hyperalgesia
效果: None
None
研究人群: mice with spinal nerve ligation-induced neuropathic pain
Other
Executive Summary of the Vulvodynia Therapeutic Research Summit.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: expert consensus on therapeutics for provoked vestibulodynia
Other
α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via …
Dose: None
vs: free alpha-lipoic acid and non-targeted nanoparticles
Outcome: seizure-induced neurotoxicity and mitochondrial homeostasis
效果: None
None
研究人群: in vitro and in vivo epilepsy models
Controlled Clinical Trial
n=24
4 weeks
Neuroprotective Effects of Alpha-Lipoic Acid Against Behavioral Toxicity, Oxidative and Inflammatory Damage Caused by Titanium …
Dose: ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p.
vs: negative control, TiO2-NPs alone, ALA alone
Outcome: neurobehavioral performance and neurodegeneration markers
效果: None
None
研究人群: male Sprague-Dawley rats
Key Statistics
8
研究数量
500
受试者
↑
Positive
C
等级
Referenced Papers
Biological trace element …
2026
2 次引用
Free radical biology …
2026
BMC neuroscience
2026
Experimental gerontology
2026
Inflammopharmacology
2026
Obstetrics and gynecology
2026
Nutrients
2025
9 次引用
Journal of stroke …
2025
4 次引用
Journal of neurotrauma
2025
Brain sciences
2025
Scientific reports
2025
Neurocritical care
2025
Environmental research
2024
33 次引用
Frontiers in nutrition
2024
9 次引用
Behavioural brain research
2024
8 次引用
Physiology & behavior
2024
3 次引用
Neuroreport
2024
3 次引用
Neurochemical research
2023
15 次引用
International immunopharmacology
2023
9 次引用
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.
Other
Antioxidants (Basel, Switzerland)
2023
5 次引用
Metabolic brain disease
2023
4 次引用
Neuroscience letters
2023
4 次引用
Antioxidants (Basel, Switzerland)
2022
22 次引用
Toxicology mechanisms and …
2022
16 次引用
Neuroscience letters
2022
16 次引用
IBRO neuroscience reports
2022
11 次引用
Journal of inflammation …
2022
9 次引用
The journal of …
2021
41 次引用
Metabolic brain disease
2021
24 次引用
Brain, behavior, and …
2020
58 次引用
Molecular neurobiology
2020
12 次引用
BMB reports
2019
29 次引用
Cellular physiology and …
2018
29 次引用
Cellular physiology and …
2018
27 次引用
Neurochemistry international
2017
53 次引用
Neurotoxicity research
2017
Neurochemistry international
2016
153 次引用
International journal of …
2016
29 次引用
Molecular neurobiology
2016
7 次引用
Minerva ginecologica
2015
International journal of …
2013
29 次引用
Evidence-based complementary and …
2011
23 次引用
Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis.
Review
Clinical nutrition (Edinburgh, …
2009
52 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 300-600 mg/day
- cognitivesupport:
- 600-1,200 mg/day (R-ALA preferred)
上限： 2,400 mg/day (highest dose in clinical trials)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 100 mg/kg/day | 8 weeks | Positive | -- |
| 50, 100, and 200 mg/kg | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p. | 4 weeks | Positive | 24 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： On empty stomach; 30 minutes before meals
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort
- ⚠ Skin rash
- ⚠ Hypoglycemia (in diabetics)
- ⚠ Headache
已知相互作用
- ● Antidiabetic drugs (may enhance blood sugar lowering)
- ● Thyroid medications (may affect thyroid hormone levels)
- ● Chemotherapy agents (may reduce efficacy of some agents)
可耐受最高摄入量： 2,400 mg/day (highest dose in clinical trials)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Alpha-Lipoic Acid help with Oxidative Stress & Neuroinflammation?
Based on 8 studies with 500 participants, there is limited but promising evidence that Alpha-Lipoic Acid may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Alpha-Lipoic Acid should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Alpha-Lipoic Acid?
Reported side effects may include Gastrointestinal discomfort, Skin rash, Hypoglycemia (in diabetics), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Alpha-Lipoic Acid and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Oxidative Stress & Neuroinflammation
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